caa a22 4500 445847786 CHVBK 20180317145404.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10548-011-0179-9 doi (NATIONALLICENCE)springer-10.1007/s10548-011-0179-9 Cortical Hemodynamic Responses to Intravenous Thiamine Propyldisulphide Administration Detected by Multichannel Near Infrared Spectroscopy (NIRS) System [Elektronische Daten] [Hiromasa Takakura, Hideo Shojaku, Kouichi Takamoto, Susumu Urakawa, Hisao Nishijo, Yukio Watanabe] Intravenous injection of thiamine propyldisulphide (TPD), which induces sensation of a garlic-like odor, has been used as a representative subjective olfactory test in Japan. However, cortical loci activated by TPD still remain unclear. We recorded cerebral hemodynamic responses (changes in Oxy-Hb concentrations) induced by TPD administration using whole-head multi-channel near infrared spectroscopy (NIRS) system based on 3D-MRIs. TPD as an odorant and saline as a control were injected from the cephalic vein in the left forearm in ten male normosmic (five young and five elderly) subjects and five dysosmic elderly patients. The all normosmic, but not dysosmic, subjects felt the garlic-like odor in the all TPD trials. There was no significant difference in hemodynamic responses between the young and elderly normosmic subjects. However, TPD injection induced significantly larger hemodynamic responses in the bilateral operculums, bilateral dorsolateral prefrontal cortices (PFC) and anteromedial PFC in the normosmic subjects, compared with saline injection. Onset latencies of these hemodynamic responses were significantly correlated with onset latencies of subjective odor sensation in the normosmic subjects. Comparison of hemodynamic responses between the normosmic and dysosmic subjects indicated a significant difference in the bilateral operculums. The results demonstrated that Oxy-Hb increases in the bilateral operculums reflected olfactory sensation induced by TPD injection. Consideration of a route for intravenous TPD to reach the olfactory mucosa suggests that these hemodynamic responses might be attributed to food-related retronasal olfactory responses to TPD. Springer Science+Business Media, LLC, 2011 NIRS nationallicence Thiamine propyldisulphide nationallicence Olfaction nationallicence Operculum nationallicence Prefrontal cortex nationallicence Takakura Hiromasa Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut Shojaku Hideo Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut Takamoto Kouichi System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut Urakawa Susumu System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut Nishijo Hisao System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut Watanabe Yukio Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut Brain Topography Springer US; http://www.springer-ny.com 24/2(2011-06-01), 114-126 0896-0267 24:2<114 2011 24 10548 https://doi.org/10.1007/s10548-011-0179-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10548-011-0179-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takakura Hiromasa Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Shojaku Hideo Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Takamoto Kouichi System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Urakawa Susumu System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Nishijo Hisao System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut NATIONALLICENCE 700 1- Watanabe Yukio Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 930-0194, Toyama, Japan aut NATIONALLICENCE 773 0- Brain Topography Springer US; http://www.springer-ny.com 24/2(2011-06-01), 114-126 0896-0267 24:2<114 2011 24 10548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer