caa a22 4500 445847840 CHVBK 20180317145404.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10548-011-0180-3 doi (NATIONALLICENCE)springer-10.1007/s10548-011-0180-3 Effect of Homobaric Pure Oxygen on Sensory Gating in the Human Brain [Elektronische Daten] [Qiu Yu, Jie Yang, Kim He, Lian Xue, Andrew Chen] Sensory gating, a viable function of the brain, is an adaptive mechanism to prevent overstimulation of nervous system. The aim of this study was to examine the effect of homobaric pure (i.e. 100%) oxygen on the human brain at different periods of inhalation. EEG was recorded while an auditory paired-click sensory gating test was conducted during 4 study periods: before inhalation of pure oxygen (Before), inhalation of 100% oxygen (air in control group) for 20min (Oxy20) and 50min (Oxy50), 30min after oxygen (air in control group) inhalation (After). Each of the auditory stimuli elicited 4 clear peaks at 20, 39, 55 and 100ms in ERPs, demonstrating that sensory gating is a multi-stage process. Comparing the S1-S2 differences of field potentials between two groups, significant experimental effects (P<0.05-0.01) were shown at Oxy50 and After periods mainly at the 20 and 100ms peak in ERPs. Pure oxygen was experimentally shown, for the first time, to affect the human brain activation, at the beginning of early P20 sensory cortical activation and late N100 auditory perception. The effect found in this study shall encourage further investigation on the oxygen treatment in human brain. Springer Science+Business Media, LLC, 2011 Pure oxygen nationallicence Auditory sensory gating nationallicence Event-related field potential (ERFP) nationallicence Field potential mapping nationallicence Yu Qiu Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, 100069, Beijing, China aut Yang Jie Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, 100069, Beijing, China aut He Kim Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, 100069, Beijing, China aut Xue Lian Department of Hyperbaric Oxygenation, Beijing Tiantan Hospital, Capital Medical University, 100050, Beijing, China aut Chen Andrew Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, 100069, Beijing, China aut Brain Topography Springer US; http://www.springer-ny.com 24/2(2011-06-01), 127-133 0896-0267 24:2<127 2011 24 10548 https://doi.org/10.1007/s10548-011-0180-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10548-011-0180-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yu Qiu Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, 100069, Beijing, China aut NATIONALLICENCE 700 1- Yang Jie Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, 100069, Beijing, China aut NATIONALLICENCE 700 1- He Kim Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, 100069, Beijing, China aut NATIONALLICENCE 700 1- Xue Lian Department of Hyperbaric Oxygenation, Beijing Tiantan Hospital, Capital Medical University, 100050, Beijing, China aut NATIONALLICENCE 700 1- Chen Andrew Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, 100069, Beijing, China aut NATIONALLICENCE 773 0- Brain Topography Springer US; http://www.springer-ny.com 24/2(2011-06-01), 127-133 0896-0267 24:2<127 2011 24 10548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer