caa a22 4500 445847891 CHVBK 20180317145404.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s10548-010-0151-0 doi (NATIONALLICENCE)springer-10.1007/s10548-010-0151-0 High Gamma Oscillations of Sensorimotor Cortex During Unilateral Movement in the Developing Brain: a MEG Study [Elektronische Daten] [Xiaolin Huo, Yingying Wang, Rupesh Kotecha, Elijah Kirtman, Hisako Fujiwara, Nat Hemasilpin, Ton Degrauw, Douglas Rose, Jing Xiang] Recent studies in adults have found consistent contralateral high gamma activities in the sensorimotor cortex during unilateral finger movement. However, no study has reported on this same phenomenon in children. We hypothesized that contralateral high gamma activities also exist in children during unilateral finger movement. Sixty normal children (6-17years old) were studied with a 275-channel MEG system combined with synthetic aperture magnetometry (SAM). Sixty participants displayed consistently contralateral event-related synchronization (C-ERS) within high gamma band (65-150Hz) in the primary motor cortices (M1) of both hemispheres. Interestingly, nineteen younger children displayed ipsilateral event-related synchronization (I-ERS) within the high gamma band (65-150Hz) just during their left finger movement. Both I-ERS and C-ERS were localized in M1. The incidence of I-ERS showed a significant decrease with age. Males had significantly higher odds of having ipsilateral activity compared to females. Noteworthy, high gamma C-ERS appeared consistently, while high gamma I-ERS changed with age. The asymmetrical patterns of neuromagnetic activities in the children's brain might represent the maturational lateralization and/or specialization of motor function. In conclusion, the present results have demonstrated that contralateral high-gamma neuromagnetic activities are potential biomarkers for the accurate localization of the primary motor cortex in children. In addition, the interesting finding of the ipsilateral high-gamma neuromagnetic activities opens a new window for us to understand the developmental changes of the hemispherical functional lateralization in the motor system. Springer Science+Business Media, LLC, 2010 Magnetoencephalography (MEG) nationallicence Sensorimotor cortex nationallicence Event-related desynchronization (ERD) nationallicence Event-related synchronization (ERS) nationallicence Synthetic aperture magnetometry (SAM) nationallicence Mirror movements (MM) nationallicence Huo Xiaolin Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut Wang Yingying Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut Kotecha Rupesh Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut Kirtman Elijah Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut Fujiwara Hisako Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut Hemasilpin Nat Department of Clinical Engineering, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA aut Degrauw Ton Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut Rose Douglas Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut Xiang Jing Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut Brain Topography Springer US; http://www.springer-ny.com 23/4(2011-01-01), 375-384 0896-0267 23:4<375 2011 23 10548 https://doi.org/10.1007/s10548-010-0151-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10548-010-0151-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huo Xiaolin Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Wang Yingying Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Kotecha Rupesh Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Kirtman Elijah Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Fujiwara Hisako Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Hemasilpin Nat Department of Clinical Engineering, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Degrauw Ton Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Rose Douglas Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Xiang Jing Department of Neurology, MLC 2015, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, 45229, Cincinnati, OH, USA aut NATIONALLICENCE 773 0- Brain Topography Springer US; http://www.springer-ny.com 23/4(2011-01-01), 375-384 0896-0267 23:4<375 2011 23 10548 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer