caa a22 4500 44585104X CHVBK 20180317145413.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10006-010-0224-y doi (NATIONALLICENCE)springer-10.1007/s10006-010-0224-y Osteonecrosis of the jaw related to sunitinib [Elektronische Daten] [Felix Koch, Christian Walter, Torsten Hansen, Elke Jäger, Wilfried Wagner] Case Report: A 59-year-old male patient was referred to the hospital with exposed bone measuring 10mm in diameter in the posterior, left-side region of the lower jaw. Two months previous, the first molar had been extracted. The patient had contracted renal cell carcinoma and had been treated by nephrectomy in 2003. Soft tissue metastases occurred. After initial therapy with interferon and vinblastine, a relapse occurred and the therapy was changed to sorafenib, followed by sunitinib. Osteonecrosis of the lower jaw appeared 1year after initial and exclusive therapy with sunitinib. Conclusions: Bisphosphonates had never been applied. With increasing application of multi-kinase inhibitors, complications due to osteonecrosis could occur more frequently. Springer-Verlag, 2010 Osteonecrosis nationallicence Sunitinib nationallicence Multi-kinase inhibitor nationallicence Side effect nationallicence Tooth extraction nationallicence Cancer therapy nationallicence Koch Felix Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University, Mund-, Kiefer-und Gesichtschirurgie, Augustusplatz 2, 55131, Mainz, Germany aut Walter Christian Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University, Mund-, Kiefer-und Gesichtschirurgie, Augustusplatz 2, 55131, Mainz, Germany aut Hansen Torsten Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany aut Jäger Elke Clinic for Oncology and Haematology, Krankenhaus Nordwest, Frankfurt a.M., Germany aut Wagner Wilfried Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University, Mund-, Kiefer-und Gesichtschirurgie, Augustusplatz 2, 55131, Mainz, Germany aut Oral and Maxillofacial Surgery Springer-Verlag 15/1(2011-03-01), 63-66 1865-1550 15:1<63 2011 15 10006 https://doi.org/10.1007/s10006-010-0224-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10006-010-0224-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koch Felix Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University, Mund-, Kiefer-und Gesichtschirurgie, Augustusplatz 2, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Walter Christian Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University, Mund-, Kiefer-und Gesichtschirurgie, Augustusplatz 2, 55131, Mainz, Germany aut NATIONALLICENCE 700 1- Hansen Torsten Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany aut NATIONALLICENCE 700 1- Jäger Elke Clinic for Oncology and Haematology, Krankenhaus Nordwest, Frankfurt a.M., Germany aut NATIONALLICENCE 700 1- Wagner Wilfried Oral and Maxillofacial Surgery, University Medical Centre of the Johannes Gutenberg University, Mund-, Kiefer-und Gesichtschirurgie, Augustusplatz 2, 55131, Mainz, Germany aut NATIONALLICENCE 773 0- Oral and Maxillofacial Surgery Springer-Verlag 15/1(2011-03-01), 63-66 1865-1550 15:1<63 2011 15 10006 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer