caa a22 4500 445851090 CHVBK 20180317145413.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10006-010-0219-8 doi (NATIONALLICENCE)springer-10.1007/s10006-010-0219-8 Areca nut in pathogenesis of oral submucous fibrosis: revisited [Elektronische Daten] [Punnya Angadi, Sanjay Rao] Background: Oral submucous fibrosis is a disease due to a chronic, insidious change in fibro-elasticity, characterized by burning sensation in the oral cavity, blanching, and stiffening of the oral mucosa and oropharynx leading to trismus and inability to open the mouth. The symptoms and signs depend on the progression of the lesions and number of affected sites. It is predominantly seen in Indians and other Asians. Once the disease has developed, there is neither regression nor any effective treatment. It is considered as a pre-malignant stage of oral cancer, and the reported risk of malignant transformation varies from 2.3-7.6%. Conclusions: The common etiological factor considered for this unremitting disease is use of areca nut; however, the precise mechanism still remains elusive and controversial. A wide range of treatment consisting of drugs, surgical therapy, and physiotherapy have been attempted till date, with varying degrees of benefit, but none of them have proved to be a cure for this disease. This field remains open for clinical trials and research. This paper aims to give an overview on the role of areca nut in the pathogenesis and malignant potential of oral submucous fibrosis. Springer-Verlag, 2010 Oral submucous fibrosis nationallicence Areca nut nationallicence Pathogenesis nationallicence Collagen synthesis nationallicence Collagen degradation nationallicence Malignant potential nationallicence Angadi Punnya Department of Oral and Maxillofacial Pathology and Microbiology, KLEVK Institute of Dental Sciences and Hospital, 590010, Belgaum, Karnataka, India aut Rao Sanjay Department of Oral and Maxillofacial Surgery, KLEVK Institute of Dental Sciences and Hospital, 590010, Belgaum, Karnataka, India aut Oral and Maxillofacial Surgery Springer-Verlag 15/1(2011-03-01), 1-9 1865-1550 15:1<1 2011 15 10006 https://doi.org/10.1007/s10006-010-0219-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10006-010-0219-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Angadi Punnya Department of Oral and Maxillofacial Pathology and Microbiology, KLEVK Institute of Dental Sciences and Hospital, 590010, Belgaum, Karnataka, India aut NATIONALLICENCE 700 1- Rao Sanjay Department of Oral and Maxillofacial Surgery, KLEVK Institute of Dental Sciences and Hospital, 590010, Belgaum, Karnataka, India aut NATIONALLICENCE 773 0- Oral and Maxillofacial Surgery Springer-Verlag 15/1(2011-03-01), 1-9 1865-1550 15:1<1 2011 15 10006 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer