caa a22 4500 445851368 CHVBK 20180317145414.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10006-010-0237-6 doi (NATIONALLICENCE)springer-10.1007/s10006-010-0237-6 Adverse effects of the amlodipine on bone healing of the mandibular fracture: an experimental study in rats [Elektronische Daten] [Rogério Moraes, Luciana Corrêa, João Luz] Background: Calcium channel blockers are effective antihypertensive agents, but they may affect many metabolic processes, including bone metabolism. Purpose: The aim of this study was to evaluate by radiographic, histologic, and biochemical analyses the effects of amlodipine on bone healing of a defect simulating a fracture in mandibular ramus of rats. Methods: Fifty male Wistar rats were submitted to the same unilateral surgical procedure simulating a mandibular fracture. Experimental group received oral doses of amlodipine 0.04mg/rat/day starting 12days before procedure, while control group received water. Animals were sacrificed at 1, 7, 14, 30, and 90days postoperatively. Numerical values were submitted to statistical analyses. Results: Radiographic analysis showed larger radiolucent area into bone defect to the experimental group at the periods of 14 (p = 0.016), 30 (p = 0.009), and 90 (p = 0.028) days. In the histological analysis, the experimental group had a slight delay in the chronology of the repair process. In the histomorphometric analysis, the experimental group presented significant lowering of newly formed bone volume at 7 and 14days periods (p = 0.049). There was a significant decrease of alkaline phosphatase levels in experimental group in the initial periods (p = 0.049). Conclusions: It was concluded that chronic use of amlodipine compromised bone neoformation in the repairing process of surgical defect in the mandibular ramus of rats, but no precluded occurrence of fracture consolidation. Springer-Verlag, 2010 Calcium channel blockers nationallicence Adverse effects nationallicence Fracture healing nationallicence Mandibular fractures nationallicence Fractures nationallicence Bone nationallicence Moraes Rogério Department of Maxillofacial Surgery, Prosthodontics and Traumatology, Dental School, University of São Paulo, São Paulo, São Paulo, Brazil aut Corrêa Luciana Department of Stomatology, Dental School, University of São Paulo, São Paulo, São Paulo, Brazil aut Luz João Department of Maxillofacial Surgery, Prosthodontics and Traumatology, Dental School, University of São Paulo, São Paulo, São Paulo, Brazil aut Oral and Maxillofacial Surgery Springer-Verlag 15/2(2011-06-01), 93-101 1865-1550 15:2<93 2011 15 10006 https://doi.org/10.1007/s10006-010-0237-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10006-010-0237-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Moraes Rogério Department of Maxillofacial Surgery, Prosthodontics and Traumatology, Dental School, University of São Paulo, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Corrêa Luciana Department of Stomatology, Dental School, University of São Paulo, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Luz João Department of Maxillofacial Surgery, Prosthodontics and Traumatology, Dental School, University of São Paulo, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 773 0- Oral and Maxillofacial Surgery Springer-Verlag 15/2(2011-06-01), 93-101 1865-1550 15:2<93 2011 15 10006 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer