caa a22 4500 445851392 CHVBK 20180317145414.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10006-010-0235-8 doi (NATIONALLICENCE)springer-10.1007/s10006-010-0235-8 Isotretinoin effect on alveolar repair after exodontia—a study in rats [Elektronische Daten] [Roberta Bergoli, Otacilio Chagas Junior, Carlos de Souza, Beatriz Vogt, Henrique de Oliveira, Adriana Etges, Daniela Silva] Objectives: To evaluate isotretinoin effect on alveolar repair after tooth extraction of maxillary incisor and serum calcium levels in rats. Study design: Wistar rats (60-day-old) were assigned to control (CG, n = 12) and experimental (EG, n = 20) groups. EG received daily isotretinoin (7.5mg/kg) for 30days before surgery and until euthanasia, 7, 21, 28, or 90days after tooth extraction. Blood was collected in the EG to analyze serum calcium levels before isotretinoin administration and at euthanasia. Right hemimaxillae underwent histological examination, and the slides were stained with HE and analyzed by descriptive light microscopy. Results: There was acceleration in the process of alveolar repair in the EG at all time points when compared to controls. Serum calcium levels showed a statistically significant decrease between first and second blood collection at days 21, 28, and 90. Conclusions: Daily isotretinoin in a dose corresponding to the treatment of cystic acne accelerated alveolar repair. Springer-Verlag, 2010 Isotretinoin nationallicence Wound healing nationallicence Bergoli Roberta Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthodontics, School of Dentistry, Universidade Federal de Pelotas (UFPEL), Rua Gonçalves Chaves, 3.657/401 B, CEP 96015-560-Bairro: Centro, Pelotas, Rio Grande do Sul, Brazil aut Chagas Junior Otacilio Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthodontics, School of Dentistry, Universidade Federal de Pelotas (UFPEL), Rua Gonçalves Chaves, 3.657/401 B, CEP 96015-560-Bairro: Centro, Pelotas, Rio Grande do Sul, Brazil aut de Souza Carlos Oral and Maxillofacial Surgery Post-Graduate Program, School of Dentistry, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil aut Vogt Beatriz Oral and Maxillofacial Surgery Post-Graduate Program, School of Dentistry, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil aut de Oliveira Henrique Dentistry Department, Fundação para Reabilitação das Deformidades Cranio Faciais (FUNDEF), Lajeado, RS, Brazil aut Etges Adriana Discipline of Oral Pathology, School of Dentistry, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil aut Silva Daniela School of Dentistry, Universidade Federal do Espírito Santo (UFES), Vitoria, ES, Brazil aut Oral and Maxillofacial Surgery Springer-Verlag 15/2(2011-06-01), 85-92 1865-1550 15:2<85 2011 15 10006 https://doi.org/10.1007/s10006-010-0235-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10006-010-0235-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bergoli Roberta Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthodontics, School of Dentistry, Universidade Federal de Pelotas (UFPEL), Rua Gonçalves Chaves, 3.657/401 B, CEP 96015-560-Bairro: Centro, Pelotas, Rio Grande do Sul, Brazil aut NATIONALLICENCE 700 1- Chagas Junior Otacilio Department of Oral and Maxillofacial Surgery and Maxillofacial Prosthodontics, School of Dentistry, Universidade Federal de Pelotas (UFPEL), Rua Gonçalves Chaves, 3.657/401 B, CEP 96015-560-Bairro: Centro, Pelotas, Rio Grande do Sul, Brazil aut NATIONALLICENCE 700 1- de Souza Carlos Oral and Maxillofacial Surgery Post-Graduate Program, School of Dentistry, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- Vogt Beatriz Oral and Maxillofacial Surgery Post-Graduate Program, School of Dentistry, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil aut NATIONALLICENCE 700 1- de Oliveira Henrique Dentistry Department, Fundação para Reabilitação das Deformidades Cranio Faciais (FUNDEF), Lajeado, RS, Brazil aut NATIONALLICENCE 700 1- Etges Adriana Discipline of Oral Pathology, School of Dentistry, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil aut NATIONALLICENCE 700 1- Silva Daniela School of Dentistry, Universidade Federal do Espírito Santo (UFES), Vitoria, ES, Brazil aut NATIONALLICENCE 773 0- Oral and Maxillofacial Surgery Springer-Verlag 15/2(2011-06-01), 85-92 1865-1550 15:2<85 2011 15 10006 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer