caa a22 4500 445852577 CHVBK 20180317145417.0 cr unu---uuuuu 170323e20110101xx s 000 0 eng 10.1007/s00204-010-0536-6 doi (NATIONALLICENCE)springer-10.1007/s00204-010-0536-6 26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice [Elektronische Daten] [Wan-Seob Cho, Jayoung Jeong, Mina Choi, Sue Park, Beom Han, Woo-Chan Son] This study examined the carcinogenic potential of di-isodecyl phthalate (DIDP) in rasH2 mice. DIDP was administered to 15 rasH2 mice/gender/group at dietary levels of 0, 0.1, 0.33, or 1% and 15 wild-type mice/gender/group at dietary levels of 0 and 1% for 26weeks. Non-neoplastic changes were observed in the liver (parenchymal inflammation, fatty changes, diffuse hepatocyte hypertrophy with eosinophilic granules and focal necrosis) and kidneys (tubular basophilia and tubular hyperplasia) after administration of DIDP in the rasH2 and wild-type mice. In the neoplastic lesions, there were a higher number of hepatocellular adenomas in the male rasH2 mice receiving 1% DIDP, compared with the findings in the liver of control rasH2 mice or wild-type mice. The incidence of hepatocellular adenomas in the 0.1, 0.33, and 1% DIDP exposed rasH2 mice was 7% (1/15), 7% (1/15), and 33% (5/15), respectively. This study adds a set of results for an additional test chemical for the performance of the rasH2 short-term transgenic model to the existing database of 3 compounds (WY-14643, DEHP, and clofibrate) tested in the ILSI/HESI ACT project. Springer-Verlag, 2010 Di-isodecyl phthalate (DIDP) nationallicence Peroxisome proliferator nationallicence rasH2 mice nationallicence 26-Week carcinogenicity study nationallicence Hepatocellular adenoma nationallicence DIDP : Di-isodecyl phthalate nationallicence MNU : N-Methyl-N-nitrosourea nationallicence DEHP : Di(2-ethylhexyl)phthalate nationallicence DINP : Di-isononyl phthalate nationallicence CIEA : Central Institute for Experimental Animals nationallicence ILSI-HESI : International Life Sciences Institute/Health and Environmental Science Institute nationallicence Tg : Transgenic nationallicence WT : Wild-type nationallicence ICH : International Conference on Harmonization nationallicence MTD : Maximum Tolerated Dose nationallicence Cho Wan-Seob ELEGI/Colt Laboratory, Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK aut Jeong Jayoung Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, 231 Jinhoungno Eunpyung-ku, 122-704, Seoul, Korea aut Choi Mina Division of Toxicological Research, National Institute of Food and Drug Safety Evaluation, 231 Jinhoungno Eunpyung-ku, 122-704, Seoul, Korea aut Park Sue Division of Toxicological Research, National Institute of Food and Drug Safety Evaluation, 231 Jinhoungno Eunpyung-ku, 122-704, Seoul, Korea aut Han Beom Good Laboratory Practice Center, Hoseo University, Sechul-ri 165, Baebang-eup, Asan city, Choongchungnam-do, South Korea aut Son Woo-Chan Department of Pathology, Huntingdon Life Sciences, Woolley Road, Alconbury, Huntingdon, PE28 4HS, Cambridgeshire, UK aut Archives of Toxicology Springer-Verlag 85/1(2011-01-01), 59-66 0340-5761 85:1<59 2011 85 204 https://doi.org/10.1007/s00204-010-0536-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-010-0536-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cho Wan-Seob ELEGI/Colt Laboratory, Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK aut NATIONALLICENCE 700 1- Jeong Jayoung Nutrition and Functional Food Research Team, National Institute of Food and Drug Safety Evaluation, 231 Jinhoungno Eunpyung-ku, 122-704, Seoul, Korea aut NATIONALLICENCE 700 1- Choi Mina Division of Toxicological Research, National Institute of Food and Drug Safety Evaluation, 231 Jinhoungno Eunpyung-ku, 122-704, Seoul, Korea aut NATIONALLICENCE 700 1- Park Sue Division of Toxicological Research, National Institute of Food and Drug Safety Evaluation, 231 Jinhoungno Eunpyung-ku, 122-704, Seoul, Korea aut NATIONALLICENCE 700 1- Han Beom Good Laboratory Practice Center, Hoseo University, Sechul-ri 165, Baebang-eup, Asan city, Choongchungnam-do, South Korea aut NATIONALLICENCE 700 1- Son Woo-Chan Department of Pathology, Huntingdon Life Sciences, Woolley Road, Alconbury, Huntingdon, PE28 4HS, Cambridgeshire, UK aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/1(2011-01-01), 59-66 0340-5761 85:1<59 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer