caa a22 4500 445852704 CHVBK 20180317145418.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00204-011-0692-3 doi (NATIONALLICENCE)springer-10.1007/s00204-011-0692-3 Reproductive toxicity parameters and biological monitoring in occupationally and environmentally boron-exposed persons in Bandırma, Turkey [Elektronische Daten] [Yalçın Duydu, Nurşen Başaran, Aylin Üstündağ, Sevtap Aydın, Ülkü Ündeğer, Osman Ataman, Kaan Aydos, Yalçın Düker, Katja Ickstadt, Britta Waltrup, Klaus Golka, Hermann Bolt] Boric acid and sodium borates have been considered as being "toxic to reproduction and development”, following results of animal studies with high doses. Experimentally, a NOAEL (no observed adverse effect level) of 17.5mg B/kg-bw/day has been identified for the (male) reproductive effects of boron in a multigeneration study of rats, and a NOAEL for the developmental effects in rats was identified at 9.6mg B/kg-bw/day. These values are being taken as the basis of current EU safety assessments. The present study was conducted to investigate the reproductive effects of boron exposure in workers employed in boric acid production plant in Bandırma, Turkey. In order to characterize the external and internal boron exposures, boron was determined in biological samples (blood, urine, semen), in workplace air, in food, and in water sources. Unfavorable effects of boron exposure on the reproductive toxicity indicators (concentration, motility, morphology of the sperm cells and blood levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and total testosterone) were not observed. The mean calculated daily boron exposure (DBE) of the highly exposed group was 14.45±6.57 (3.32-35.62) mg/day. These human exposures represent worst-case exposure conditions to boric acid/borates in Turkey. These exposure levels are considerably lower than exposures, which have previously led to reproductive effects in experimental animals. In conclusion, this means that dose levels of boron associated with developmental and reproductive toxic effects in animals are by far not reachable for humans under conditions of normal handling and use. Springer-Verlag, 2011 Boron nationallicence Boric acid nationallicence Daily boron exposure nationallicence Reproductive toxicity nationallicence Semen nationallicence Biological monitoring nationallicence Duydu Yalçın Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandoğan, Ankara, Turkey aut Başaran Nurşen Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100, Sıhhiye, Ankara, Turkey aut Üstündağ Aylin Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandoğan, Ankara, Turkey aut Aydın Sevtap Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100, Sıhhiye, Ankara, Turkey aut Ündeğer Ülkü Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100, Sıhhiye, Ankara, Turkey aut Ataman Osman Department of Chemistry, Middle East Technical University, 06531, Ankara, Turkey aut Aydos Kaan Department of Urology, Faculty of Medicine, Ankara University, 06100, Ankara, Turkey aut Düker Yalçın Bandırma State Hospital, Bandırma, Turkey aut Ickstadt Katja Faculty of Statistics, TU Dortmund, 44221, Dortmund, Germany aut Waltrup Britta Faculty of Statistics, TU Dortmund, 44221, Dortmund, Germany aut Golka Klaus Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut Bolt Hermann Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut Archives of Toxicology Springer-Verlag 85/6(2011-06-01), 589-600 0340-5761 85:6<589 2011 85 204 https://doi.org/10.1007/s00204-011-0692-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0692-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Duydu Yalçın Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandoğan, Ankara, Turkey aut NATIONALLICENCE 700 1- Başaran Nurşen Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100, Sıhhiye, Ankara, Turkey aut NATIONALLICENCE 700 1- Üstündağ Aylin Department of Toxicology, Faculty of Pharmacy, Ankara University, 06100, Tandoğan, Ankara, Turkey aut NATIONALLICENCE 700 1- Aydın Sevtap Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100, Sıhhiye, Ankara, Turkey aut NATIONALLICENCE 700 1- Ündeğer Ülkü Department of Toxicology, Faculty of Pharmacy, Hacettepe University, 06100, Sıhhiye, Ankara, Turkey aut NATIONALLICENCE 700 1- Ataman Osman Department of Chemistry, Middle East Technical University, 06531, Ankara, Turkey aut NATIONALLICENCE 700 1- Aydos Kaan Department of Urology, Faculty of Medicine, Ankara University, 06100, Ankara, Turkey aut NATIONALLICENCE 700 1- Düker Yalçın Bandırma State Hospital, Bandırma, Turkey aut NATIONALLICENCE 700 1- Ickstadt Katja Faculty of Statistics, TU Dortmund, 44221, Dortmund, Germany aut NATIONALLICENCE 700 1- Waltrup Britta Faculty of Statistics, TU Dortmund, 44221, Dortmund, Germany aut NATIONALLICENCE 700 1- Golka Klaus Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut NATIONALLICENCE 700 1- Bolt Hermann Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/6(2011-06-01), 589-600 0340-5761 85:6<589 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer