caa a22 4500 445852844 CHVBK 20180317145418.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00204-011-0651-z doi (NATIONALLICENCE)springer-10.1007/s00204-011-0651-z In vivo and ex vivo percutaneous absorption of [14C]-bisphenol A in rats: a possible extrapolation to human absorption? [Elektronische Daten] [Fabrice Marquet, Jean-Paul Payan, Dominique Beydon, Ludivine Wathier, Marie-Christine Grandclaude, Elisabeth Ferrari] Bisphenol A (BPA) is a monomer used mainly in the synthesis of polycarbonates and epoxy resins. Percutaneous absorption is the second source of exposure, after inhalation, in the work environment. However, studies on this route of absorption are lacking or incomplete. In this study, percutaneous BPA absorption was measured in vivo and ex vivo in the rat, and ex vivo in humans. An approximately 12-fold difference in permeability between rat skin and human skin was found, with permeability being higher in the rat. In addition, inter- and intra-individual variability of up to tenfold was observed in humans. No accumulation of BPA in the skin was found during exposure. The skin clearance rate following exposure was estimated at 0.4μg/cm²/h. Ex vivo and in vivo percutaneous absorption fluxes of BPA in the rat were in the same range (about 2.0μg/cm²/h), suggesting that extrapolation to the in vivo situation in humans may be possible. The European tolerable daily intake (TDI) of BPA is 50μg/kg body weight. However, many research projects have highlighted the significant effects of BPA in rodents at doses lower than 10μg/kg/day. A 1-h occupational exposure over 2,000cm² (forearms and hands) may lead to a BPA absorption of 4μg/kg/day. This is 8% of the European TDI and is very close to the value at which effects have been observed in animals. This absorption must therefore be taken into account when evaluating risks of BPA exposure, at least until more relevant results on the toxicity of BPA in humans are available. The Author(s), 2011 Bisphenol A nationallicence Percutaneous absorption nationallicence Rat nationallicence Human nationallicence In vivo nationallicence Ex vivo nationallicence BPA : Bisphenol A nationallicence CERHR : Center for evaluation of risks to human reproduction nationallicence EFSA : European food safety authority nationallicence HPLC : High performance liquid chromatography nationallicence LOAEL : Lowest observed adverse effect level nationallicence NTP : National toxicology program nationallicence TDI : Tolerable daily intake nationallicence TEWL : Trans-epidermal water loss nationallicence Marquet Fabrice Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut Payan Jean-Paul Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut Beydon Dominique Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut Wathier Ludivine Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut Grandclaude Marie-Christine Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut Ferrari Elisabeth Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut Archives of Toxicology Springer-Verlag 85/9(2011-09-01), 1035-1043 0340-5761 85:9<1035 2011 85 204 https://doi.org/10.1007/s00204-011-0651-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0651-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marquet Fabrice Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut NATIONALLICENCE 700 1- Payan Jean-Paul Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut NATIONALLICENCE 700 1- Beydon Dominique Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut NATIONALLICENCE 700 1- Wathier Ludivine Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut NATIONALLICENCE 700 1- Grandclaude Marie-Christine Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut NATIONALLICENCE 700 1- Ferrari Elisabeth Institut National de Recherche et de Sécurité, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/9(2011-09-01), 1035-1043 0340-5761 85:9<1035 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer