caa a22 4500 445852895 CHVBK 20180317145418.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s00204-011-0653-x doi (NATIONALLICENCE)springer-10.1007/s00204-011-0653-x DNA damage in fetal liver cells of turkey and chicken eggs dosed with aflatoxin B1 [Elektronische Daten] [J. Williams, U. Deschl, G. Williams] The present study was undertaken to investigate the potential of the potent hepatocarcinogen aflatoxin B1 (AFB) to produce DNA damage in turkey and chicken fetal livers in ovo. Effects of a single injection of two different doses (0.062 and 6.2μg) of AFB were examined under both short-term (4h) and longer-term (4day) dosing of eggs from turkeys at 24days and chickens at 18days of development. Liver cells prepared from the fetuses were used to assess the extent of DNA damage by the alkaline single-cell gel electrophoresis (comet) assay. The results demonstrate that AFB produces dose-related DNA damage in the fetal livers of both turkeys and chicken at 4h, which was reduced by 4days. Turkey embryos appeared to be slightly more susceptible to AFB damage, although no difference in the survival between chicken and turkey fetuses was observed. Springer-Verlag, 2011 Aflatoxin B1 nationallicence DNA damage nationallicence Liver nationallicence Turkey nationallicence Chicken nationallicence Williams J. Department of Pathology, New York Medical College, 10595, Valhalla, NY, USA aut Deschl U. Department of Non-Clinical Drug Safety, Boehringer Ingelheim Pharma KG, Biberach/Riss, Germany aut Williams G. Department of Pathology, New York Medical College, 10595, Valhalla, NY, USA aut Archives of Toxicology Springer-Verlag 85/9(2011-09-01), 1167-1172 0340-5761 85:9<1167 2011 85 204 https://doi.org/10.1007/s00204-011-0653-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0653-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Williams J. Department of Pathology, New York Medical College, 10595, Valhalla, NY, USA aut NATIONALLICENCE 700 1- Deschl U. Department of Non-Clinical Drug Safety, Boehringer Ingelheim Pharma KG, Biberach/Riss, Germany aut NATIONALLICENCE 700 1- Williams G. Department of Pathology, New York Medical College, 10595, Valhalla, NY, USA aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/9(2011-09-01), 1167-1172 0340-5761 85:9<1167 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer