caa a22 4500 445853034 CHVBK 20180317145419.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00204-010-0546-4 doi (NATIONALLICENCE)springer-10.1007/s00204-010-0546-4 Nanoparticles: molecular targets and cell signalling [Elektronische Daten] [Francelyne Marano, Salik Hussain, Fernando Rodrigues-Lima, Armelle Baeza-Squiban, Sonja Boland] Increasing evidence linking nanoparticles (NPs) with different cellular outcomes necessitate an urgent need for the better understanding of cellular signalling pathways triggered by NPs. Oxidative stress has largely been reported to be implicated in NP-induced toxicity. It could activate a wide variety of cellular events such as cell cycle arrest, apoptosis, inflammation and induction of antioxidant enzymes. These responses occur after the activation of different cellular pathways. In this context, three groups of MAP kinase cascades [ERK (extracellular signal-regulated kinases), p38 mitogen-activated protein kinase and JNK (c-Jun N-terminal kinases)] as well as redox-sensitive transcription factors such as NFκB and Nrf-2 were specially investigated. The ability of NPs to interact with these signalling pathways could partially explain their cytotoxicity. The induction of apoptosis is also closely related to the modulation of signalling pathways induced by NPs. Newly emerged scientific areas of research are the studies on interactions between NPs and biological molecules in body fluids, cellular microenvironment, intracellular components or secreted cellular proteins such as cytokines, growth factors and enzymes and use of engineered NPs to target various signal transduction pathways in cancer therapy. Recently published data present the ability of NPs to interact with membrane receptors leading to a possible aggregation of these receptors. These interactions could lead to a sustained modulation of specific signalling in the target cells or paracrine and even "by-stander” effects of the neighbouring cells or tissues. However, oxidative stress is not sufficient to explain specific mechanisms which could be induced by NPs, and these new findings emphasize the need to revise the paradigm of oxidative stress to explain the effects of NPs. Springer-Verlag, 2010 Nanoparticle nationallicence Oxidative stress nationallicence Cell signalling nationallicence Inflammation nationallicence Nano-bio interactions nationallicence Apoptosis nationallicence Marano Francelyne Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut Hussain Salik Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut Rodrigues-Lima Fernando Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut Baeza-Squiban Armelle Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut Boland Sonja Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut Archives of Toxicology Springer-Verlag 85/7(2011-07-01), 733-741 0340-5761 85:7<733 2011 85 204 https://doi.org/10.1007/s00204-010-0546-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-010-0546-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Marano Francelyne Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut NATIONALLICENCE 700 1- Hussain Salik Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut NATIONALLICENCE 700 1- Rodrigues-Lima Fernando Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut NATIONALLICENCE 700 1- Baeza-Squiban Armelle Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut NATIONALLICENCE 700 1- Boland Sonja Unit of Functional and Adaptive Biology (BFA) CNRS EAC 4413, Laboratory of Molecular and Cellular Responses to Xenobiotics, Université Paris Diderot—Paris 7, Bâtiment Buffon 3ème étage, Case Courrier 7073, 5 rue Thomas Mann, 75205, Paris cedex 13, France aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/7(2011-07-01), 733-741 0340-5761 85:7<733 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer