caa a22 4500 445853123 CHVBK 20180317145419.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00204-011-0728-8 doi (NATIONALLICENCE)springer-10.1007/s00204-011-0728-8 Calabrese Edward Environmental Health Sciences, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, 01003, Amherst, MA, USA aut Muller's Nobel lecture on dose-response for ionizing radiation: ideology or science? [Elektronische Daten] [Edward Calabrese] In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose-response for radiation-induced germ cell mutations was linear and that there was "no escape from the conclusion that there is no threshold”. However, assessment of correspondence between Muller and Curt Stern 1month prior to his Nobel Prize Lecture reveals that Muller knew the results and implications of a recently completed study at the University of Rochester under the direction of Stern, which directly contradicted his Nobel Prize Lecture. This finding is of historical importance since Muller's Nobel Lecture gained considerable international attention and is a turning point in the acceptance of the linearity model in risk assessment for germ cell mutations and carcinogens. Springer-Verlag, 2011 Linearity nationallicence Threshold nationallicence Hermann J. Muller nationallicence Nobel Prize nationallicence Risk assessment nationallicence X-rays nationallicence Ionizing radiation nationallicence Archives of Toxicology Springer-Verlag 85/12(2011-12-01), 1495-1498 0340-5761 85:12<1495 2011 85 204 https://doi.org/10.1007/s00204-011-0728-8 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0728-8 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Calabrese Edward Environmental Health Sciences, Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts, 01003, Amherst, MA, USA aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/12(2011-12-01), 1495-1498 0340-5761 85:12<1495 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer