caa a22 4500 445853360 CHVBK 20180317145420.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00204-010-0626-5 doi (NATIONALLICENCE)springer-10.1007/s00204-010-0626-5 Nephrotoxicity of contrast media and protective effects of acetylcysteine [Elektronische Daten] [Carlo Briguori, Cristina Quintavalle, Francesca De Micco, Gerolama Condorelli] Contrast-induced acute kidney injury (CI-AKI) accounts for approximately 10% of all causes of hospital-acquired renal failure, causes a prolonged in-hospital stay, and represents a powerful predictor of poor early and late outcome. N-acetylcysteine (NAC) is a thiol compound classically known as a mucolytic agent, which is a potent antioxidant that scavenges a wide variety of oxygen-derived-free-radicals and may be capable of preventing acute kidney injury. In the present study, we will review (1) the pathophysiology of the CI-AKI and (2) the experimental and clinical data on the effects of NAC in preventing CI-AKI. Springer-Verlag, 2010 Kidney nationallicence Contrast media nationallicence NAC nationallicence Apoptosis nationallicence Acetylcysteine nationallicence Briguori Carlo Clinica Mediterranea, Laboratory of Interventional Cardiology, Via Orazio, 2, 80121, Naples, Italy aut Quintavalle Cristina Department of Cellular and Molecular Biology and Pathology, and IEOS, CNR, Federico II University of Naples, Via Pansini, 5, 80121, Naples, Italy aut De Micco Francesca IRCCS Multimedica, Milan, Italy aut Condorelli Gerolama Fondazione SDN, Via Gianturco 113, 80121, Naples, Italy aut Archives of Toxicology Springer-Verlag 85/3(2011-03-01), 165-173 0340-5761 85:3<165 2011 85 204 https://doi.org/10.1007/s00204-010-0626-5 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-010-0626-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Briguori Carlo Clinica Mediterranea, Laboratory of Interventional Cardiology, Via Orazio, 2, 80121, Naples, Italy aut NATIONALLICENCE 700 1- Quintavalle Cristina Department of Cellular and Molecular Biology and Pathology, and IEOS, CNR, Federico II University of Naples, Via Pansini, 5, 80121, Naples, Italy aut NATIONALLICENCE 700 1- De Micco Francesca IRCCS Multimedica, Milan, Italy aut NATIONALLICENCE 700 1- Condorelli Gerolama Fondazione SDN, Via Gianturco 113, 80121, Naples, Italy aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/3(2011-03-01), 165-173 0340-5761 85:3<165 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer