caa a22 4500 445853425 CHVBK 20180317145420.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00204-011-0659-4 doi (NATIONALLICENCE)springer-10.1007/s00204-011-0659-4 Genotoxicity and carcinogenicity studies of antihistamines [Elektronische Daten] [Giovanni Brambilla, Francesca Mattioli, Luigi Robbiano, Antonietta Martelli] This review provides a compendium of the results of genotoxicity and carcinogenicity assays performed on marketed antihistamines. Of the 70 drugs examined, 29 (41.4%) have at least one genotoxicity and/or carcinogenicity test result: 12 tested positive in at least one genotoxicity assay, six in at least one carcinogenicity assay, and four gave a positive response in both at least one genotoxicity assay and at least one carcinogenicity assay. Of 19 drugs with both genotoxicity and carcinogenicity data, eight were neither genotoxic nor carcinogenic, two were carcinogenic in at least one sex of mice or rats but tested negative in genotoxicity assays, five tested positive in at least one genotoxicity assay but were non-carcinogenic, and four gave a positive response in at least one genotoxicity assay and in at least one carcinogenicity assay. Only 12 (17.1%) of the 70 drugs examined have all data required by present guidelines for testing of pharmaceuticals, but it should be considered that a large fraction of them were developed and marketed prior the present regulatory climate. Springer-Verlag, 2011 Antihistamines nationallicence Genotoxicity nationallicence Carcinogenicity nationallicence Brambilla Giovanni Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, 16132, Genoa, Italy aut Mattioli Francesca Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, 16132, Genoa, Italy aut Robbiano Luigi Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, 16132, Genoa, Italy aut Martelli Antonietta Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, 16132, Genoa, Italy aut Archives of Toxicology Springer-Verlag 85/10(2011-10-01), 1173-1187 0340-5761 85:10<1173 2011 85 204 https://doi.org/10.1007/s00204-011-0659-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0659-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brambilla Giovanni Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Mattioli Francesca Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Robbiano Luigi Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, 16132, Genoa, Italy aut NATIONALLICENCE 700 1- Martelli Antonietta Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Viale Benedetto XV 2, 16132, Genoa, Italy aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/10(2011-10-01), 1173-1187 0340-5761 85:10<1173 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer