caa a22 4500 44585345X CHVBK 20180317145420.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00204-011-0668-3 doi (NATIONALLICENCE)springer-10.1007/s00204-011-0668-3 Combined analysis of chromosomal aberrations and glutathione S-transferase M1 and T1 polymorphisms in pathologists occupationally exposed to formaldehyde [Elektronische Daten] [Alfredo Santovito, Tiziana Schilirò, Sergio Castellano, Piero Cervella, Maria Bigatti, Giorgio Gilli, Roberto Bono, Massimiliano DelPero] The formaldehyde (FA) genotoxic potential in occupationally exposed individuals is conflicting. A relevant indoor-air FA pollution was found in hospitals and scientific institutions where FA is used as a bactericide and tissue preservative. In the present study, we evaluated the frequency of chromosomal aberrations (CAs) in peripheral blood lymphocytes from workers in pathology wards who have been exposed to FA, compared with a group of unexposed subjects. The subjects were also analyzed for the GSTM1 and GSTT1 metabolic gene polymorphisms. The exposed subjects showed a significant increase in the frequency of CA per cell and in the percentage of cells with aberrations compared to control subjects. The different GST genotypes did not affect the level of cytogenetic damage since CA frequencies were not statistically different between the GST "null” genotypes and the GST "positives”. The generalized linear models showed that the number of CAs and cells with CAs increased with age, but, independent of age, it was significantly higher in the experimental rather than in the control group. Cubic-spline regression confirmed the linear relationship between CAs and age, but it provided evidence for a non-linear relationship between CAs and the number of years of FA exposure. Similar results were observed when the model included the number of cells with CAs as dependent variables. Our results demonstrate that air FA induces CAs even consequently to low levels of daily exposure, indicating an increased risk of genetic damage for workers exposed to this air pollutant. Springer-Verlag, 2011 Biomonitoring nationallicence Toxicology nationallicence Exposure monitoring nationallicence Formaldehyde nationallicence Polymorphisms nationallicence Santovito Alfredo Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut Schilirò Tiziana Department of Public Health and Microbiology, University of Torino, Turin, Italy aut Castellano Sergio Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut Cervella Piero Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut Bigatti Maria Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut Gilli Giorgio Department of Public Health and Microbiology, University of Torino, Turin, Italy aut Bono Roberto Department of Public Health and Microbiology, University of Torino, Turin, Italy aut DelPero Massimiliano Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut Archives of Toxicology Springer-Verlag 85/10(2011-10-01), 1295-1302 0340-5761 85:10<1295 2011 85 204 https://doi.org/10.1007/s00204-011-0668-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0668-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Santovito Alfredo Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut NATIONALLICENCE 700 1- Schilirò Tiziana Department of Public Health and Microbiology, University of Torino, Turin, Italy aut NATIONALLICENCE 700 1- Castellano Sergio Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut NATIONALLICENCE 700 1- Cervella Piero Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut NATIONALLICENCE 700 1- Bigatti Maria Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut NATIONALLICENCE 700 1- Gilli Giorgio Department of Public Health and Microbiology, University of Torino, Turin, Italy aut NATIONALLICENCE 700 1- Bono Roberto Department of Public Health and Microbiology, University of Torino, Turin, Italy aut NATIONALLICENCE 700 1- DelPero Massimiliano Department of Animal and Human Biology, University of Torino, Via Accademia Albertina n. 13, 10123, Turin, Italy aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/10(2011-10-01), 1295-1302 0340-5761 85:10<1295 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer