caa a22 4500 445853484 CHVBK 20180317145421.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00204-011-0669-2 doi (NATIONALLICENCE)springer-10.1007/s00204-011-0669-2 Quantitative cancer risk assessment for ethylene oxide inhalation in occupational settings [Elektronische Daten] [Ciriaco Valdez-Flores, Robert Sielken Jr, M. Jane Teta] The estimated occupational ethylene oxide (EO) exposure concentrations corresponding to specified extra risks are calculated for lymphoid mortality as the most appropriate endpoint, despite the lack of a statistically significant exposure-response relationship. These estimated concentrations are for occupational exposures—40years of occupational inhalation exposure to EO from age 20 to age 60years. The estimated occupational inhalation exposure concentrations (ppm) corresponding to specified extra risks of lymphoid mortality to age 70years in a population of male and female EO workers are based on Cox proportional hazards models of the most recent updated epidemiology cohort mortality studies of EO workers and a standard life-table calculation. An occupational exposure at an inhalation concentration of 2.77ppm EO is estimated to result in an extra risk of lymphoid mortality of 4 in 10,000 (0.0004) in the combined worker population of men and women from the two studies. The corresponding estimated concentration decreases slightly to 2.27ppm when based on only the men in the updated cohorts combined. The difference in these estimates reflects the difference between combining all of the available data or focusing on only the men and excluding the women who did not show an increase in lymphoid mortality with EO inhalation exposure. The results of sensitivity analyses using other mortality endpoints (all lymphohematopoietic tissue cancers, leukemia) support the choice of lymphoid tumor mortality for estimation of extra risk. Springer-Verlag, 2011 Ethylene oxide nationallicence Excess cancer risk calculation for occupational inhalation exposure nationallicence NIOSH and UCC epidemiology data nationallicence Cox proportional hazards models nationallicence Lymphoid mortality nationallicence Dow : Dow Chemical Company nationallicence EO : Ethylene oxide nationallicence IARC : International Agency for Research on Cancer nationallicence NIOSH : National Institute for Occupational Safety and Health nationallicence SMR : Standardized mortality ratio nationallicence UCC : Union Carbide Corporation nationallicence Valdez-Flores Ciriaco Sielken & Associates Consulting Inc., 3833 South Texas Avenue, Suite 230, 77802, Bryan, TX, USA aut Sielken Jr Robert Sielken & Associates Consulting Inc., 3833 South Texas Avenue, Suite 230, 77802, Bryan, TX, USA aut Jane Teta M. Exponent Health Sciences, 8 Dogwood Court, 06762, Middlebury, CT, USA aut Archives of Toxicology Springer-Verlag 85/10(2011-10-01), 1189-1193 0340-5761 85:10<1189 2011 85 204 https://doi.org/10.1007/s00204-011-0669-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0669-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Valdez-Flores Ciriaco Sielken & Associates Consulting Inc., 3833 South Texas Avenue, Suite 230, 77802, Bryan, TX, USA aut NATIONALLICENCE 700 1- Sielken Jr Robert Sielken & Associates Consulting Inc., 3833 South Texas Avenue, Suite 230, 77802, Bryan, TX, USA aut NATIONALLICENCE 700 1- Jane Teta M. Exponent Health Sciences, 8 Dogwood Court, 06762, Middlebury, CT, USA aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/10(2011-10-01), 1189-1193 0340-5761 85:10<1189 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer