caa a22 4500 445853514 CHVBK 20180317145421.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00204-011-0662-9 doi (NATIONALLICENCE)springer-10.1007/s00204-011-0662-9 Genetic background of resistance to cadmium-induced testicular toxicity in inbred Wistar-Imamichi rats [Elektronische Daten] [Hideaki Shimada, Iori Hata, Takashi Hashiguchi, Yorishige Imamura] We have previously reported that inbred Wistar-Imamichi (WI) rats are highly resistant to cadmium (Cd)-induced testicular toxicity compared with inbred Fischer 344 (F344) rats. The present study was to elucidate the genetic background of resistance to Cd-induced testicular toxicity in WI rats. The genetic analysis of susceptibility to Cd-induced testicular toxicity was conducted by using Cd-resistant WI and Cd-sensitive F344 strains as the parental rats and by using the testicular hemoglobin level as the indicator. In the frequency distribution of testicular hemoglobin levels in parental, first filial (F1) and second filial (F2) rats treated with Cd at a dose of 2.0mg/kg, F1 rats had testicular hemoglobin levels intermediate to WI and F344 rats, and F2 rats segregated into three groups of low, intermediate, and high phenotypes at the expected ratio. Furthermore, the backcross progeny between WI and F1 or between F344 and F1 segregated into two groups with the expected ratio. Based on a simple Mendelian genetic analysis, these segregation patterns lead us to conclude that two codominant alleles at a gene locus are responsible for the susceptibility to Cd-induced testicular toxicity in rats. This is the first report for the genetic analysis of susceptibility to Cd-induced testicular toxicity in inbred rat strains. Springer-Verlag, 2011 Cadmium nationallicence Testicular toxicity nationallicence Susceptibility nationallicence Strain difference nationallicence Genetic analysis nationallicence Inbred rat nationallicence Shimada Hideaki Faculty of Education, Kumamoto University, 2-40-1 Kurokami, 860-8555, Kumamoto, Japan aut Hata Iori Faculty of Education, Kumamoto University, 2-40-1 Kurokami, 860-8555, Kumamoto, Japan aut Hashiguchi Takashi Faculty of Education, Kumamoto University, 2-40-1 Kurokami, 860-8555, Kumamoto, Japan aut Imamura Yorishige Nihon Pharmaceutical University, 10281 Komuro, 362-0806, Saitama, Japan aut Archives of Toxicology Springer-Verlag 85/10(2011-10-01), 1195-1199 0340-5761 85:10<1195 2011 85 204 https://doi.org/10.1007/s00204-011-0662-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0662-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shimada Hideaki Faculty of Education, Kumamoto University, 2-40-1 Kurokami, 860-8555, Kumamoto, Japan aut NATIONALLICENCE 700 1- Hata Iori Faculty of Education, Kumamoto University, 2-40-1 Kurokami, 860-8555, Kumamoto, Japan aut NATIONALLICENCE 700 1- Hashiguchi Takashi Faculty of Education, Kumamoto University, 2-40-1 Kurokami, 860-8555, Kumamoto, Japan aut NATIONALLICENCE 700 1- Imamura Yorishige Nihon Pharmaceutical University, 10281 Komuro, 362-0806, Saitama, Japan aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/10(2011-10-01), 1195-1199 0340-5761 85:10<1195 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer