caa a22 4500 445853565 CHVBK 20180317145421.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00204-011-0681-6 doi (NATIONALLICENCE)springer-10.1007/s00204-011-0681-6 Irritative effects of vapours and aerosols of bitumen on the airways assessed by non-invasive methods [Elektronische Daten] [Monika Raulf-Heimsoth, Beate Pesch, Benjamin Kendzia, Anne Spickenheuer, Rainer Bramer, Boleslaw Marczynski, Rolf Merget, Thomas Brüning] Irritative effects caused by vapours and aerosols of bitumen were assessed by non-invasive methods including spirometry, nasal lavage fluid (NALF) and induced sputum (IS) in a cross-shift study comparing 320 bitumen-exposed workers with 118 road construction workers as the reference group. Lung function parameters, forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were within normal ranges in both the reference and the bitumen-exposed groups pre- and post-shift with marginally lower values in smokers of both groups. During the shift, a slight decline in FEV1 and FVC was observed in the bitumen-exposed group independent of their smoking habits, whereas in the non-smoking reference group, the decline in FEV1 was not observed. No significant differences between bitumen-exposed workers and the reference group and no significant shift effect were observed on the upper airways using NALF analysis. The IS concentrations of interleukin (IL)-8, total protein and matrix metalloproteinase-9 were significantly higher in bitumen-exposed workers than in the reference group. However, the concentration of these three biomarkers in the IS samples, which are indicators of inflammatory effects on the lower airways of bitumen-exposed workers, was already higher in exposed workers before shift and did not show an increase during the shift. Therefore, the key finding of this aspect of the Human Bitumen Study is the detection of potentially (sub-) chronic irritative inflammatory effects in the lower airways of bitumen-exposed workers. Springer-Verlag, 2011 Bitumen nationallicence Irritative effects nationallicence Cross-shift design nationallicence Nasal lavage nationallicence Induced sputum nationallicence Cellular and soluble biomarkers nationallicence Raulf-Heimsoth Monika Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut Pesch Beate Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut Kendzia Benjamin Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut Spickenheuer Anne Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut Bramer Rainer Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut Marczynski Boleslaw Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut Merget Rolf Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut Brüning Thomas Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut Archives of Toxicology Springer-Verlag 85(2011-06-01), 41-52 0340-5761 85<41 2011 85 204 https://doi.org/10.1007/s00204-011-0681-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0681-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Raulf-Heimsoth Monika Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut NATIONALLICENCE 700 1- Pesch Beate Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut NATIONALLICENCE 700 1- Kendzia Benjamin Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut NATIONALLICENCE 700 1- Spickenheuer Anne Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut NATIONALLICENCE 700 1- Bramer Rainer Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut NATIONALLICENCE 700 1- Marczynski Boleslaw Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut NATIONALLICENCE 700 1- Merget Rolf Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut NATIONALLICENCE 700 1- Brüning Thomas Institute of Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Germany aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85(2011-06-01), 41-52 0340-5761 85<41 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer