caa a22 4500 445853646 CHVBK 20180317145421.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00204-010-0588-7 doi (NATIONALLICENCE)springer-10.1007/s00204-010-0588-7 Fluoride-induced histopathology and synthesis of stress protein in liver and kidney of mice [Elektronische Daten] [Ansuman Chattopadhyay, Santosh Podder, Soumik Agarwal, Shelley Bhattacharya] Selective low (15mg sodium fluoride (NaF)/L) and relatively high (150mg NaF/L) doses of in vivo fluoride (F) treatment to Swiss albino mice through drinking water elicited organ-specific toxicological response. All the F-exposed groups showed severe alterations in both liver and kidney architectures, but there was no significant change in the rate of water consumption and body weight. Vacuolar degeneration, micronecrotic foci in the hepatocytes, and hepatocellular hypertrophy were evident in the mice exposed to low dose (15mg NaF/L for 30days) while sinusoidal dilation with enlarged central vein surrounded by deep-blue erythrocytes were preponderant when treated with the same dose for a period of 90days. Blood filled spaces, disintegration of tubular epithelium, and atrophy of glomeruli were also recorded in the kidney of the same treatment group. Change in reduced glutathione level (GSH), glutathione-s-transferase (GST) activity, malondialdehyde (MDA) production in both liver and kidney, disturbances in liver function, induction of heat shock protein 70 (Hsp 70) expression in kidney and its down regulation in liver were positively correlated with histopathological lesion. Springer-Verlag, 2010 Sodium fluoride nationallicence Genotoxicity nationallicence Heat shock protein 70 nationallicence Hepatotoxicity nationallicence Histopathology nationallicence Liver function nationallicence Nephrotoxicity nationallicence Chattopadhyay Ansuman Radiation Genetics and Chemical Mutagenesis Laboratory, Department of Zoology, Centre for Advanced Studies, Visva-Bharati University, 731 235, Santiniketan, India aut Podder Santosh Radiation Genetics and Chemical Mutagenesis Laboratory, Department of Zoology, Centre for Advanced Studies, Visva-Bharati University, 731 235, Santiniketan, India aut Agarwal Soumik Environmental Toxicology Laboratory, Department of Zoology, Centre for Advanced Studies, Visva-Bharati University, 731 235, Santiniketan, India aut Bhattacharya Shelley Environmental Toxicology Laboratory, Department of Zoology, Centre for Advanced Studies, Visva-Bharati University, 731 235, Santiniketan, India aut Archives of Toxicology Springer-Verlag 85/4(2011-04-01), 327-335 0340-5761 85:4<327 2011 85 204 https://doi.org/10.1007/s00204-010-0588-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-010-0588-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chattopadhyay Ansuman Radiation Genetics and Chemical Mutagenesis Laboratory, Department of Zoology, Centre for Advanced Studies, Visva-Bharati University, 731 235, Santiniketan, India aut NATIONALLICENCE 700 1- Podder Santosh Radiation Genetics and Chemical Mutagenesis Laboratory, Department of Zoology, Centre for Advanced Studies, Visva-Bharati University, 731 235, Santiniketan, India aut NATIONALLICENCE 700 1- Agarwal Soumik Environmental Toxicology Laboratory, Department of Zoology, Centre for Advanced Studies, Visva-Bharati University, 731 235, Santiniketan, India aut NATIONALLICENCE 700 1- Bhattacharya Shelley Environmental Toxicology Laboratory, Department of Zoology, Centre for Advanced Studies, Visva-Bharati University, 731 235, Santiniketan, India aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/4(2011-04-01), 327-335 0340-5761 85:4<327 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer