caa a22 4500 44585376X CHVBK 20180317145421.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00204-011-0648-7 doi (NATIONALLICENCE)springer-10.1007/s00204-011-0648-7 Carcinogenicity of deoxycholate, a secondary bile acid [Elektronische Daten] [Carol Bernstein, Hana Holubec, Achyut Bhattacharyya, Huy Nguyen, Claire Payne, Beryl Zaitlin, Harris Bernstein] High dietary fat causes increased bile acid secretion into the gastrointestinal tract and is associated with colon cancer. Since the bile acid deoxycholic acid (DOC) is suggested to be important in colon cancer etiology, this study investigated whether DOC, at a high physiologic level, could be a colon carcinogen. Addition of 0.2% DOC for 8-10months to the diet of 18 wild-type mice induced colonic tumors in 17 mice, including 10 with cancers. Addition of the antioxidant chlorogenic acid at 0.007% to the DOC-supplemented diet significantly reduced tumor formation. These results indicate that a high fat diet in humans, associated with increased risk of colon cancer, may have its carcinogenic potential mediated through the action of bile acids, and that some dietary anti-oxidants may ameliorate this carcinogenicity. The Author(s), 2011 Colon cancer nationallicence Deoxycholate nationallicence Adenocarcinoma nationallicence Chlorogenic acid nationallicence Bernstein Carol Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut Holubec Hana Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut Bhattacharyya Achyut Arizona Cancer Center, University of Arizona, Tucson, AZ, USA aut Nguyen Huy Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut Payne Claire Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut Zaitlin Beryl Department of Civil Engineering, University of Calgary, Calgary, AB, Canada aut Bernstein Harris Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut Archives of Toxicology Springer-Verlag 85/8(2011-08-01), 863-871 0340-5761 85:8<863 2011 85 204 https://doi.org/10.1007/s00204-011-0648-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0648-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Bernstein Carol Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Holubec Hana Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Bhattacharyya Achyut Arizona Cancer Center, University of Arizona, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Nguyen Huy Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Payne Claire Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut NATIONALLICENCE 700 1- Zaitlin Beryl Department of Civil Engineering, University of Calgary, Calgary, AB, Canada aut NATIONALLICENCE 700 1- Bernstein Harris Department of Cell Biology and Anatomy, College of Medicine, University of Arizona, 85724-5044, Tucson, AZ, USA aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/8(2011-08-01), 863-871 0340-5761 85:8<863 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer