caa a22 4500 445853816 CHVBK 20180317145422.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00204-010-0620-y doi (NATIONALLICENCE)springer-10.1007/s00204-010-0620-y An in vivo assessment of the genotoxic potential of bisphenol A and 4-tert-octylphenol in rats [Elektronische Daten] [Onur Ulutaş, Nurçin Yıldız, Emre Durmaz, Müfide Ahbab, Nurhayat Barlas, İsmet Çok] Bisphenol A (BPA) and octylphenol (OP) are industrial chemicals used in the manufacture of polycarbonate plastics, epoxy resins, and non-ionic surfactants. In the present study, we investigated the possible in vivo genotoxic effects of these compounds in rats using single-cell gel electrophoresis, the so-called comet assay. Adult male Wistar albino rats were divided randomly into six groups as follows: BPA125 (received 125mg/kg bw BPA; n=6), OP125 (received 125mg/kg bw OP; n=6), BPA250 (received 250mg/kg BPA; n=6), OP250 (received 250mg/kg bw OP; n=6), control (n=5), and MMS (positive control group that received methyl methanesulfonate; n=3). Both BPA and OP were orally administrated for 4weeks. Controls were orally inoculated with corn oil for 4weeks as well. Comet parameters including tail length and tail moment were evaluated for possible genotoxic effects. There were no significant differences in the OP125 and in the BPA125 compared with the control group, regarding tail length and tail moment (P>0.05). However, there were significant differences in the OP250 and in the BPA250 compared with the control group, regarding tail length and tail moment (P<0.05 and P<0.01, respectively). The genotoxic potential of BPA and OP was investigated in vivo; there is a need for further studies exploring further mechanisms of the genotoxic potential of these chemicals in vivo. Springer-Verlag, 2010 Bisphenol A nationallicence Octylphenol nationallicence Genotoxicity nationallicence Comet assay nationallicence Rat nationallicence Ulutaş Onur Faculty of Pharmacy, Department of Toxicology, Gazi University, 06330, Hipodrom, Ankara, Turkey aut Yıldız Nurçin Faculty of Science, Department of Biology, Hacettepe University, 06800, Beytepe, Ankara, Turkey aut Durmaz Emre Faculty of Pharmacy, Department of Toxicology, Gazi University, 06330, Hipodrom, Ankara, Turkey aut Ahbab Müfide Faculty of Science, Department of Biology, Hacettepe University, 06800, Beytepe, Ankara, Turkey aut Barlas Nurhayat Faculty of Science, Department of Biology, Hacettepe University, 06800, Beytepe, Ankara, Turkey aut Çok İsmet Faculty of Pharmacy, Department of Toxicology, Gazi University, 06330, Hipodrom, Ankara, Turkey aut Archives of Toxicology Springer-Verlag 85/8(2011-08-01), 995-1001 0340-5761 85:8<995 2011 85 204 https://doi.org/10.1007/s00204-010-0620-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-010-0620-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ulutaş Onur Faculty of Pharmacy, Department of Toxicology, Gazi University, 06330, Hipodrom, Ankara, Turkey aut NATIONALLICENCE 700 1- Yıldız Nurçin Faculty of Science, Department of Biology, Hacettepe University, 06800, Beytepe, Ankara, Turkey aut NATIONALLICENCE 700 1- Durmaz Emre Faculty of Pharmacy, Department of Toxicology, Gazi University, 06330, Hipodrom, Ankara, Turkey aut NATIONALLICENCE 700 1- Ahbab Müfide Faculty of Science, Department of Biology, Hacettepe University, 06800, Beytepe, Ankara, Turkey aut NATIONALLICENCE 700 1- Barlas Nurhayat Faculty of Science, Department of Biology, Hacettepe University, 06800, Beytepe, Ankara, Turkey aut NATIONALLICENCE 700 1- Çok İsmet Faculty of Pharmacy, Department of Toxicology, Gazi University, 06330, Hipodrom, Ankara, Turkey aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/8(2011-08-01), 995-1001 0340-5761 85:8<995 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer