caa a22 4500 445853956 CHVBK 20180317145422.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s00204-010-0601-1 doi (NATIONALLICENCE)springer-10.1007/s00204-010-0601-1 Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats [Elektronische Daten] [James Antonini, Jenny Roberts, Samuel Stone, Bean Chen, Diane Schwegler-Berry, Rebecca Chapman, Patti Zeidler-Erdely, Ronnee Andrews, David Frazer] Welding generates complex metal fumes that vary in composition. The objectives of this study were to compare the persistence of deposited metals and the inflammatory potential of stainless and mild steel welding fumes, the two most common fumes used in US industry. Sprague-Dawley rats were exposed to 40mg/m3 of stainless or mild steel welding fumes for 3h/day for 3days. Controls were exposed to filtered air. Generated fume was collected, and particle size and elemental composition were determined. Bronchoalveolar lavage was done on days 0, 8, 21, and 42 after the last exposure to assess lung injury/inflammation and to recover lung phagocytes. Non-lavaged lung samples were analyzed for total and specific metal content as a measure of metal persistence. Both welding fumes were similar in particle morphology and size. Following was the chemical composition of the fumes—stainless steel: 57% Fe, 20% Cr, 14% Mn, and 9% Ni; mild steel: 83% Fe and 15% Mn. There was no effect of the mild steel fume on lung injury/inflammation at any time point compared to air control. Lung injury and inflammation were significantly elevated at 8 and 21days after exposure to the stainless steel fume compared to control. Stainless steel fume exposure was associated with greater recovery of welding fume-laden macrophages from the lungs at all time points compared with the mild steel fume. A higher concentration of total metal was observed in the lungs of the stainless steel welding fume at all time points compared with the mild steel fume. The specific metals present in the two fumes were cleared from the lungs at different rates. The potentially more toxic metals (e.g., Mn, Cr) present in the stainless steel fume were cleared from the lungs more quickly than Fe, likely increasing their translocation from the respiratory system to other organs. Springer-Verlag (outside the USA), 2010 Welding fume nationallicence Inhalation nationallicence Lung burden nationallicence Lung clearance nationallicence Pulmonary toxicity nationallicence Antonini James Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut Roberts Jenny Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut Stone Samuel Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut Chen Bean Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut Schwegler-Berry Diane Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut Chapman Rebecca Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut Zeidler-Erdely Patti Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut Andrews Ronnee Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 45213, Cincinnati, OH, USA aut Frazer David Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut Archives of Toxicology Springer-Verlag 85/5(2011-05-01), 487-498 0340-5761 85:5<487 2011 85 204 https://doi.org/10.1007/s00204-010-0601-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-010-0601-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Antonini James Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Roberts Jenny Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Stone Samuel Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Chen Bean Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Schwegler-Berry Diane Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Chapman Rebecca Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Zeidler-Erdely Patti Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Andrews Ronnee Division of Applied Research and Technology, National Institute for Occupational Safety and Health, 45213, Cincinnati, OH, USA aut NATIONALLICENCE 700 1- Frazer David Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, 26505, Morgantown, WV, USA aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/5(2011-05-01), 487-498 0340-5761 85:5<487 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer