caa a22 4500 445853980 CHVBK 20180317145422.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00204-010-0568-y doi (NATIONALLICENCE)springer-10.1007/s00204-010-0568-y Genetic variants associated with arsenic metabolism within human arsenic (+3 oxidation state) methyltransferase show wide variation across multiple populations [Elektronische Daten] [Junko Fujihara, Toshihiro Yasuda, Hideaki Kato, Isao Yuasa, Arturo Panduro, Takashi Kunito, Haruo Takeshita] Human arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. The objective of this study was to investigate the diversity of the AS3MT gene in Mexican and German populations. The distribution of 18 single nucleotide polymorphisms (SNPs) in AS3MT was assessed on healthy individuals: 38 Mestizo, 69 Nahuas, 50 Huicholes, and 32 Germans. All 18 SNPs were polymorphic in the German and Mexican populations. Of the three Mexican populations, a minor allele frequency was the highest in the Mestizo, followed by the Nahuas and Huicholes. In the German and three Mexican groups, haplotype #1(TATAGAAGTCTTCATGAC) was the most predominant. Seven haplotypes were newly found in the German and three Mexican populations. The D′ values between SNP pairs were high in the German and Nahua populations; they had a similar pattern. The pattern of the Mestizo was more similar to the African than to the other Mexican populations. Huicholes had a moderate pattern of the African and German/Nahua populations. The network had three clusters. One originated in the African population and another may have originated in an Asian (Chinese and/or Japanese) population. The third one may have originated among Caucasians. This study is the first to demonstrate the existence of genetic heterogeneity in the distribution of 18 SNPs in AS3MT of German and Mexican populations. Springer-Verlag, 2010 Arsenic (+3 oxidation state) methyltransferase (AS3MT) nationallicence Ethnic differences nationallicence Genetic variation nationallicence Haplotype nationallicence Linkage disequilibrium nationallicence Single nucleotide polymorphisms (SNPs) nationallicence Mexican nationallicence German nationallicence Fujihara Junko Department of Legal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya, 693-8501, Izumo, Shimane, Japan aut Yasuda Toshihiro Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Fukui, Japan aut Kato Hideaki Department of Forensic Medicine, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Fukui, Japan aut Yuasa Isao Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan aut Panduro Arturo Department of Molecular Biology in Medicine, Old Civil Hospital of Guadalajara and Health Sciences Center, University of Guadalajara, Guadalajara, Mexico aut Kunito Takashi Department of Environmental Sciences, Faculty of Science, Shinshu University, Matsumoto, Nagano, Japan aut Takeshita Haruo Department of Legal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya, 693-8501, Izumo, Shimane, Japan aut Archives of Toxicology Springer-Verlag 85/2(2011-02-01), 119-125 0340-5761 85:2<119 2011 85 204 https://doi.org/10.1007/s00204-010-0568-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-010-0568-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fujihara Junko Department of Legal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya, 693-8501, Izumo, Shimane, Japan aut NATIONALLICENCE 700 1- Yasuda Toshihiro Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Eiheiji-cho, Fukui, Japan aut NATIONALLICENCE 700 1- Kato Hideaki Department of Forensic Medicine, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Fukui, Japan aut NATIONALLICENCE 700 1- Yuasa Isao Division of Legal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan aut NATIONALLICENCE 700 1- Panduro Arturo Department of Molecular Biology in Medicine, Old Civil Hospital of Guadalajara and Health Sciences Center, University of Guadalajara, Guadalajara, Mexico aut NATIONALLICENCE 700 1- Kunito Takashi Department of Environmental Sciences, Faculty of Science, Shinshu University, Matsumoto, Nagano, Japan aut NATIONALLICENCE 700 1- Takeshita Haruo Department of Legal Medicine, Faculty of Medicine, Shimane University, 89-1 Enya, 693-8501, Izumo, Shimane, Japan aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/2(2011-02-01), 119-125 0340-5761 85:2<119 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer