caa a22 4500 445854138 CHVBK 20180317145423.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s00204-011-0687-0 doi (NATIONALLICENCE)springer-10.1007/s00204-011-0687-0 Anti-apoptotic, anti-inflammatory, and immunomodulatory activities of 3,3′-diselenodipropionic acid in mice exposed to whole body γ-radiation [Elektronische Daten] [A. Kunwar, P. Bag, S. Chattopadhyay, V. Jain, K. Priyadarsini] The present study was designed to evaluate the possible protective effects of 3,3′-diselenodipropionic acid (DSePA), a potent radioprotector, against oxidative organ damage induced by whole body γ-irradiation and explore its mechanistic effects. The mice were subjected to whole body γ-irradiation at 5Gy for the detection of oxidative stress, apoptosis, and proliferation in the intestinal (jejunum) tissue and at 7Gy for the examination of intestinal inflammation and immune imbalance. Groups of mice received intraperitoneal injections of DSePA (2mg/kg/day) or vehicle (phosphate-buffered saline) for 5 consecutive days prior to irradiation. The whole body γ-irradiation of mice led to the induction of oxidative stress and apoptosis in the intestinal tissue, and pretreatment with DSePA significantly reduced both these parameters. It was also found to abrogate the radiation-induced intestinal inflammatory response and augment the proliferation of intestinal cells. Additionally, irradiation-induced polarization of Th1/Th2 immune balance toward the Th2-dominant direction and pretreatment with DSePA ameliorated this shift, which may be beneficial for the recovery from radiation injury. In conclusion, pretreatment with DSePA prevented radiation-induced oxidative damage in small intestine and the underlying mechanisms responsible for this could be attributed to inhibition of oxidative stress, apoptosis, and inflammation. Springer-Verlag, 2011 Apoptosis nationallicence Diselenodipropionic acid nationallicence Intestine nationallicence Inflammation nationallicence Proliferation nationallicence γ-Radiation nationallicence Kunwar A. Radiation and Photochemistry Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut Bag P. Radiation and Photochemistry Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut Chattopadhyay S. Bio-Organic Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut Jain V. Chemistry Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut Priyadarsini K. Radiation and Photochemistry Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut Archives of Toxicology Springer-Verlag 85/11(2011-11-01), 1395-1405 0340-5761 85:11<1395 2011 85 204 https://doi.org/10.1007/s00204-011-0687-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00204-011-0687-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kunwar A. Radiation and Photochemistry Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut NATIONALLICENCE 700 1- Bag P. Radiation and Photochemistry Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut NATIONALLICENCE 700 1- Chattopadhyay S. Bio-Organic Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut NATIONALLICENCE 700 1- Jain V. Chemistry Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut NATIONALLICENCE 700 1- Priyadarsini K. Radiation and Photochemistry Division, Bhabha Atomic Research Centre, 400085, Mumbai, India aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 85/11(2011-11-01), 1395-1405 0340-5761 85:11<1395 2011 85 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer