caa a22 4500 445856890 CHVBK 20180317145430.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10592-009-9990-1 doi (NATIONALLICENCE)springer-10.1007/s10592-009-9990-1 A shared unusual genetic change at the chemokine receptor type 5 between Oryctolagus , Bunolagus and Pentalagus [Elektronische Daten] [Joana Abrantes, Catarina Carmo, Conrad Matthee, Fumio Yamada, Wessel van der Loo, Pedro Esteves] Whereas in most leporid species studied the effects of exposure to Myxoma virus (MV) are benign, in the European rabbit (Oryctolagus cuniculus) it causes an epizootic disease with particularly high mortality rates, known as myxomatosis. Chemokine receptors are known to play an important role in infection by large DNA viruses such as MV, by acting as portals for viral entry into the host cell. As with the human immunodeficiency virus, CCR5 is among the major candidates to affect resistance to myxomatosis. Previous sequence comparisons of the CCR5 gene among Leporid species revealed that a drastic change occurred at the second extracellular loop which was unique to the European rabbit species. Here we report that European rabbit shares this particular alteration with two of its closest relatives: the South African Riverine rabbit (Bunolagus monticularis) and the Japanese Amami rabbit (Pentalagus furnessi). Both species represent monotypic genera and are included in the IUCN Red List as Endangered. It would then be urgent to study the susceptibility of these species to myxomatosis. Despite the lack of direct evidence that the altered CCR5 can affect the outcome of exposure to MV, the reported findings justify preventive measures to be considered. Springer Science+Business Media B.V., 2009 Chemokine receptors nationallicence Gene conversion nationallicence Myxomatosis nationallicence Riverine rabbit ( Bunolagus monticularis ) nationallicence Amami rabbit ( Pentalagus furnessi ) nationallicence European rabbit ( Oryctolagus cuniculus ) nationallicence Abrantes Joana CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal aut Carmo Catarina CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal aut Matthee Conrad Evolutionary Genomics Group, Department of Botany and Zoology, Stellenbosch University, 7602, Stellenbosch, South Africa aut Yamada Fumio Kanasi Research Center, Forestry and Forest Products Research Institute, Kyoto, Japan aut van der Loo Wessel CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal aut Esteves Pedro CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal aut Conservation Genetics Springer Netherlands 12/1(2011-02-01), 325-330 1566-0621 12:1<325 2011 12 10592 https://doi.org/10.1007/s10592-009-9990-1 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10592-009-9990-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abrantes Joana CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal aut NATIONALLICENCE 700 1- Carmo Catarina CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal aut NATIONALLICENCE 700 1- Matthee Conrad Evolutionary Genomics Group, Department of Botany and Zoology, Stellenbosch University, 7602, Stellenbosch, South Africa aut NATIONALLICENCE 700 1- Yamada Fumio Kanasi Research Center, Forestry and Forest Products Research Institute, Kyoto, Japan aut NATIONALLICENCE 700 1- van der Loo Wessel CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal aut NATIONALLICENCE 700 1- Esteves Pedro CIBIO, Centro de Investigação em Biodiversidade e Recursos Genéticos, Campus Agrário de Vairão, Vairão, Portugal aut NATIONALLICENCE 773 0- Conservation Genetics Springer Netherlands 12/1(2011-02-01), 325-330 1566-0621 12:1<325 2011 12 10592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer