caa a22 4500 445856904 CHVBK 20180317145430.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10592-009-9998-6 doi (NATIONALLICENCE)springer-10.1007/s10592-009-9998-6 MHC diversity in bottlenecked populations: a simulation model [Elektronische Daten] [Maciej Ejsmond, Jacek Radwan] The depletion of variation at MHC loci, which play a crucial role in pathogen recognition, has been postulated to be one of important extinction risk factors for endangered populations. Thus, it is important to understand how selection affects the level of polymorphism in these genes when populations undergo a reduction in size. We followed MHC diversity in computer simulations of population bottlenecks. The fates of MHC alleles in the simulations were determined either by drift, or by balancing selection resulting from host-parasite coevolution. We found that the impact of selection on MHC polymorphism in bottlenecked populations was dependent upon the timescales involved. Initially, selection maintained lower number of alleles than drift, but after ~40 generations of hosts selection maintained higher MHC diversity, as compared to drift. The adverse effects of decreased MHC polymorphism on population viability may be, to some extent, compensated for if selection helps to retain MHC alleles which show high functional diversity, which should allow protection against a broader range of pathogens. Our simulation shows, however, that the mean divergence of alleles retained under selection in bottlenecked populations is not, on average, significantly higher than the divergence due to drift. Springer Science+Business Media B.V., 2009 Major histocompatibility complex nationallicence Balancing selection nationallicence Conservation nationallicence Extinction nationallicence Bottleneck nationallicence Ejsmond Maciej Institute of Environmental Sciences, Jagiellonian University, Krakow, Poland aut Radwan Jacek Institute of Nature Conservation, Polish Academy of Sciences, Krakow, Poland aut Conservation Genetics Springer Netherlands 12/1(2011-02-01), 129-137 1566-0621 12:1<129 2011 12 10592 https://doi.org/10.1007/s10592-009-9998-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10592-009-9998-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ejsmond Maciej Institute of Environmental Sciences, Jagiellonian University, Krakow, Poland aut NATIONALLICENCE 700 1- Radwan Jacek Institute of Nature Conservation, Polish Academy of Sciences, Krakow, Poland aut NATIONALLICENCE 773 0- Conservation Genetics Springer Netherlands 12/1(2011-02-01), 129-137 1566-0621 12:1<129 2011 12 10592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer