caa a22 4500 445858125 CHVBK 20180317145434.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10592-010-0147-z doi (NATIONALLICENCE)springer-10.1007/s10592-010-0147-z Inbreeding, heterozygosity and fitness in a reintroduced population of endangered African wild dogs ( Lycaon pictus ) [Elektronische Daten] [Penny Spiering, Micaela Szykman Gunther, Michael Somers, David Wildt, Michele Walters, Amy Wilson, Jesús Maldonado] It is crucial to understand the genetic health and implications of inbreeding in wildlife populations, especially of vulnerable species. Using extensive demographic and genetic data, we investigated the relationships among pedigree inbreeding coefficients, metrics of molecular heterozygosity and fitness for a large population of endangered African wild dogs (Lycaon pictus) in South Africa. Molecular metrics based on 19 microsatellite loci were significantly, but modestly correlated to inbreeding coefficients in this population. Inbred wild dogs with inbreeding coefficients of ≥0.25 and subordinate individuals had shorter lifespans than outbred and dominant contemporaries, suggesting some deleterious effects of inbreeding. However, this trend was confounded by pack-specific effects as many inbred individuals originated from a single large pack. Despite wild dogs being endangered and existing in small populations, findings within our sample population indicated that molecular metrics were not robust predictors in models of fitness based on breeding pack formation, dominance, reproductive success or lifespan of individuals. Nonetheless, our approach has generated a vital database for future comparative studies to examine these relationships over longer periods of time. Such detailed assessments are essential given knowledge that wild canids can be highly vulnerable to inbreeding effects over a few short generations. Springer Science+Business Media B.V., 2010 Endangered nationallicence Heterozygosity-fitness correlation nationallicence Inbreeding nationallicence Lifespan nationallicence Lycaon pictus nationallicence Spiering Penny Center for Conservation and Evolutionary Genetics, Smithsonian Conservation Biology Institute, National Zoological Park, 20008, Washington, DC, USA aut Szykman Gunther Micaela Center for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, 22630, Front Royal, VA, USA aut Somers Michael Centre for Wildlife Management, University of Pretoria, 0002, Pretoria, South Africa aut Wildt David Center for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, 22630, Front Royal, VA, USA aut Walters Michele Centre for Wildlife Management, University of Pretoria, 0002, Pretoria, South Africa aut Wilson Amy Center for Conservation and Evolutionary Genetics, Smithsonian Conservation Biology Institute, National Zoological Park, 20008, Washington, DC, USA aut Maldonado Jesús Center for Conservation and Evolutionary Genetics, Smithsonian Conservation Biology Institute, National Zoological Park, 20008, Washington, DC, USA aut Conservation Genetics Springer Netherlands 12/2(2011-04-01), 401-412 1566-0621 12:2<401 2011 12 10592 https://doi.org/10.1007/s10592-010-0147-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10592-010-0147-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Spiering Penny Center for Conservation and Evolutionary Genetics, Smithsonian Conservation Biology Institute, National Zoological Park, 20008, Washington, DC, USA aut NATIONALLICENCE 700 1- Szykman Gunther Micaela Center for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, 22630, Front Royal, VA, USA aut NATIONALLICENCE 700 1- Somers Michael Centre for Wildlife Management, University of Pretoria, 0002, Pretoria, South Africa aut NATIONALLICENCE 700 1- Wildt David Center for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, 22630, Front Royal, VA, USA aut NATIONALLICENCE 700 1- Walters Michele Centre for Wildlife Management, University of Pretoria, 0002, Pretoria, South Africa aut NATIONALLICENCE 700 1- Wilson Amy Center for Conservation and Evolutionary Genetics, Smithsonian Conservation Biology Institute, National Zoological Park, 20008, Washington, DC, USA aut NATIONALLICENCE 700 1- Maldonado Jesús Center for Conservation and Evolutionary Genetics, Smithsonian Conservation Biology Institute, National Zoological Park, 20008, Washington, DC, USA aut NATIONALLICENCE 773 0- Conservation Genetics Springer Netherlands 12/2(2011-04-01), 401-412 1566-0621 12:2<401 2011 12 10592 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer