caa a22 4500 445860499 CHVBK 20180317145441.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00439-011-1028-3 doi (NATIONALLICENCE)springer-10.1007/s00439-011-1028-3 Offit Kenneth Clinical Genetics Service, Department of Medicine, Program in Cancer Biology and Genetics, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 10021, New York, NY, USA aut Personalized medicine: new genomics, old lessons [Elektronische Daten] [Kenneth Offit] Personalized medicine uses traditional, as well as emerging concepts of the genetic and environmental basis of disease to individualize prevention, diagnosis and treatment. Personalized genomics plays a vital, but not exclusive role in this evolving model of personalized medicine. The distinctions between genetic and genomic medicine are more quantitative than qualitative. Personalized genomics builds on principles established by the integration of genetics into medical practice. Principles shared by genetic and genomic aspects of medicine, include the use of variants as markers for diagnosis, prognosis, prevention, as well as targets for treatment, the use of clinically validated variants that may not be functionally characterized, the segregation of these variants in non-Mendelian as well as Mendelian patterns, the role of gene-environment interactions, the dependence on evidence for clinical utility, the critical translational role of behavioral science, and common ethical considerations. During the current period of transition from investigation to practice, consumers should be protected from harms of premature translation of research findings, while encouraging the innovative and cost-effective application of those genomic discoveries that improve personalized medical care. The Author(s), 2011 Human Genetics Springer-Verlag 130/1(2011-07-01), 3-14 0340-6717 130:1<3 2011 130 439 https://doi.org/10.1007/s00439-011-1028-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-1028-3 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Offit Kenneth Clinical Genetics Service, Department of Medicine, Program in Cancer Biology and Genetics, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, 10021, New York, NY, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/1(2011-07-01), 3-14 0340-6717 130:1<3 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer