caa a22 4500 445860537 CHVBK 20180317145441.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00439-011-1010-0 doi (NATIONALLICENCE)springer-10.1007/s00439-011-1010-0 Somatic variation and cancer: therapies lost in the mix [Elektronische Daten] [Andrew Biankin, Thomas Hudson] Cancer arises as a consequence of mutations in genomes of cancer cells, which over time allow them to proliferate and spread to distant sites. Large-scale sequencing of cancer genomes is revealing an increasing number of potential driver mutations that may allow specific targeting of cancer genes, proteins, and pathways. Comprehensive views of cancer genomes are also revealing enormous heterogeneity of mutation profiles, even among tumours derived from the same organs and having similar pathological characteristics. There are now many examples where mutation profiles observed in tumours have been shown to correlate with clinical features of disease, drug response, and patient outcomes. When ignored, molecular heterogeneity can lead to failures in drug development, as drugs that may have efficacy in subgroups of patients with specific molecular phenotypes may show marginal response when tested in large groups of unselected patients. This article explores issues relevant to the clinical translation of sequence-based mutation profiles in the clinical development of targeted therapies and in the future management of cancer patients. Springer-Verlag, 2011 Biankin Andrew Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, 2010, Sydney, NSW, Australia aut Hudson Thomas Ontario Institute for Cancer Research, 101 College Street, M5G 0A3, Toronto, ON, Canada aut Human Genetics Springer-Verlag 130/1(2011-07-01), 79-91 0340-6717 130:1<79 2011 130 439 https://doi.org/10.1007/s00439-011-1010-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-1010-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Biankin Andrew Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St, Darlinghurst, 2010, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Hudson Thomas Ontario Institute for Cancer Research, 101 College Street, M5G 0A3, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/1(2011-07-01), 79-91 0340-6717 130:1<79 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer