caa a22 4500 445860561 CHVBK 20180317145441.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00439-011-0986-9 doi (NATIONALLICENCE)springer-10.1007/s00439-011-0986-9 Genomic markers to tailor treatments: waiting or initiating? [Elektronische Daten] [Parvin Tajik, Patrick Bossuyt] The decade since the publication of the Human Genome Project draft has ended with the discovery of hundreds of genomic markers related to diseases and phenotypes. However, the project has not yet delivered on its promise to tailor treatments for individuals. The number of genomic markers in clinical practice is very small. The number of markers to guide treatment decisions is even smaller. In order to speed up discovery and validation of genomic treatment selection markers, we call for considering the brilliant potential of randomized clinical trials. If biomedical research community can collaborate in organizing large-scale consortium of clinical trials associated with well-designed biobanks, these studies would soon act as huge laboratories for investigating genomic medicine; a big step forward towards personalizing medicine. The Author(s), 2011 Tajik Parvin Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Room J1b-214, PO Box 22700, 1100 DE, Amsterdam, The Netherlands aut Bossuyt Patrick Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Room J1b-214, PO Box 22700, 1100 DE, Amsterdam, The Netherlands aut Human Genetics Springer-Verlag 130/1(2011-07-01), 15-18 0340-6717 130:1<15 2011 130 439 https://doi.org/10.1007/s00439-011-0986-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-0986-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tajik Parvin Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Room J1b-214, PO Box 22700, 1100 DE, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Bossuyt Patrick Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Room J1b-214, PO Box 22700, 1100 DE, Amsterdam, The Netherlands aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/1(2011-07-01), 15-18 0340-6717 130:1<15 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer