caa a22 4500 445860618 CHVBK 20180317145441.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00439-011-1022-9 doi (NATIONALLICENCE)springer-10.1007/s00439-011-1022-9 Friedman Judith Office of History, National Institutes of Health, Bldg 45, 3AN38, MSC 6330, 20892-6330, Bethesda, MD, USA aut Anticipation in hereditary disease: the history of a biomedical concept [Elektronische Daten] [Judith Friedman] In the mid-nineteenth century, it was commonly believed that hereditary disease struck at the same time in succeeding generations, except for those cases in which it appeared at an earlier age. This exception to the rule was the precursor for the concept of anticipation in hereditary disease, a pattern of inheritance where a hereditary illness strikes earlier and often more severely in succeeding generations. Anticipation underwent cycles of acceptance and rejection over the course of the twentieth century and the ways in which this concept was received reveal complex interactions between science, medicine, and society. Springer-Verlag (outside the USA), 2011 Human Genetics Springer-Verlag 130/6(2011-12-01), 705-714 0340-6717 130:6<705 2011 130 439 https://doi.org/10.1007/s00439-011-1022-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-1022-9 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Friedman Judith Office of History, National Institutes of Health, Bldg 45, 3AN38, MSC 6330, 20892-6330, Bethesda, MD, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/6(2011-12-01), 705-714 0340-6717 130:6<705 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer