caa a22 4500 445860642 CHVBK 20180317145441.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s00439-011-1026-5 doi (NATIONALLICENCE)springer-10.1007/s00439-011-1026-5 A miRNA-492 binding-site polymorphism in BSG ( basigin ) confers risk to psoriasis in Central South Chinese population [Elektronische Daten] [Li-Sha Wu, Fang-Fang Li, Liang-Dan Sun, Dai Li, Juan Su, Ye-Hong Kuang, Gang Chen, Xiao-Ping Chen, Xiang Chen] Psoriasis (PS; MIM#177900) is a chronic inflammatory immune-mediated skin disorder. Although the disease is believed to be caused by a combination of genetic, immunologic and environmental factors, its complete etiology has not been fully understood. Here, we focused on the BSG (MIM#109480), a member of the immunoglobulin superfamily expressed ubiquitously in circulating immune cell populations. We observed that the expression level of BSG in PBMCs was elevated in psoriasis patients. To understand the underlying mechanism for this change, we genotyped the rs8259 T>A SNP located in the 3′UTR of the BSG gene from 668 psoriasis patients and 1,143 healthy controls. The rs8259 T allele was associated with significantly decreased psoriasis susceptibility (OR=0.758, 95% CI 0.638-0.901, p=0.002). Interestingly, the rs8259 polymorphism was located in a seed region for miR-492 binding. The miR-492 was able to bind to the BSG 3′UTR sequence bearing the rs8259 T allele as assayed by luciferase reporter gene assay. The substitution of T with A abolished miR-492 binding. BSG protein expression in PBMCs from patients carrying the rs8259 AA genotype was significantly higher than in those from patients carrying the rs8259 TT genotype. Our study suggests that miR-492 may physiologically suppress BSG expression and the BSG rs8259 polymorphism is associated with decreased psoriasis susceptibility through affecting miR-492 binding. Springer-Verlag, 2011 Wu Li-Sha Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut Li Fang-Fang Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut Sun Liang-Dan State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Hefei, Anhui, People's Republic of China aut Li Dai Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut Su Juan Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut Kuang Ye-Hong Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut Chen Gang State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Hefei, Anhui, People's Republic of China aut Chen Xiao-Ping Department of Pharmacology, School of Pharmaceutical Science, Central South University, 410078, Changsha, Hunan, China aut Chen Xiang Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut Human Genetics Springer-Verlag 130/6(2011-12-01), 749-757 0340-6717 130:6<749 2011 130 439 https://doi.org/10.1007/s00439-011-1026-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-1026-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Li-Sha Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 700 1- Li Fang-Fang Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 700 1- Sun Liang-Dan State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Hefei, Anhui, People's Republic of China aut NATIONALLICENCE 700 1- Li Dai Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 700 1- Su Juan Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 700 1- Kuang Ye-Hong Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 700 1- Chen Gang State Key Laboratory Incubation Base of Dermatology, Ministry of National Science and Technology, Hefei, Anhui, People's Republic of China aut NATIONALLICENCE 700 1- Chen Xiao-Ping Department of Pharmacology, School of Pharmaceutical Science, Central South University, 410078, Changsha, Hunan, China aut NATIONALLICENCE 700 1- Chen Xiang Department of Dermatology, Xiang-Ya Hospital, Central South University, 87 XiangYa Road, 410008, Changsha, Hunan, People's Republic of China aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/6(2011-12-01), 749-757 0340-6717 130:6<749 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer