caa a22 4500 44586088X CHVBK 20180317145442.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00439-011-0983-z doi (NATIONALLICENCE)springer-10.1007/s00439-011-0983-z Integrative computational biology for cancer research [Elektronische Daten] [Kristen Fortney, Igor Jurisica] Over the past two decades, high-throughput (HTP) technologies such as microarrays and mass spectrometry have fundamentally changed clinical cancer research. They have revealed novel molecular markers of cancer subtypes, metastasis, and drug sensitivity and resistance. Some have been translated into the clinic as tools for early disease diagnosis, prognosis, and individualized treatment and response monitoring. Despite these successes, many challenges remain: HTP platforms are often noisy and suffer from false positives and false negatives; optimal analysis and successful validation require complex workflows; and great volumes of data are accumulating at a rapid pace. Here we discuss these challenges, and show how integrative computational biology can help diminish them by creating new software tools, analytical methods, and data standards. The Author(s), 2011 Fortney Kristen Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada aut Jurisica Igor Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada aut Human Genetics Springer-Verlag 130/4(2011-10-01), 465-481 0340-6717 130:4<465 2011 130 439 https://doi.org/10.1007/s00439-011-0983-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-0983-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fortney Kristen Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 700 1- Jurisica Igor Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/4(2011-10-01), 465-481 0340-6717 130:4<465 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer