caa a22 4500 445861134 CHVBK 20180317145443.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00439-011-1002-0 doi (NATIONALLICENCE)springer-10.1007/s00439-011-1002-0 Mechanistic insights into chromosome-wide silencing in X inactivation [Elektronische Daten] [Susanne Arthold, Agata Kurowski, Anton Wutz] In mammals, one of the two X chromosomes in female cells is transcriptionally silenced for dosage compensation between the sexes. Chromosome-wide silencing is initiated by the non-coding Xist RNA that accumulates within the inactive X chromosome territory and triggers gene repression and chromatin modifications. Epigenetic changes of the inactive X chromosome in a developmentally regulated manner result in stable gene repression in female somatic cells. X inactivation is a model for understanding the formation of facultative heterochromatin in mammalian development and represents a paradigm for RNA mediated regulation of gene expression. In this review, we summarize the present knowledge of the mechanism of chromosome-wide silencing and give an outlook on future directions. Springer-Verlag, 2011 Arthold Susanne Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, CB2 1QR, Cambridge, UK aut Kurowski Agata Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, CB2 1QR, Cambridge, UK aut Wutz Anton Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, CB2 1QR, Cambridge, UK aut Human Genetics Springer-Verlag 130/2(2011-08-01), 295-305 0340-6717 130:2<295 2011 130 439 https://doi.org/10.1007/s00439-011-1002-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-1002-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Arthold Susanne Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, CB2 1QR, Cambridge, UK aut NATIONALLICENCE 700 1- Kurowski Agata Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, CB2 1QR, Cambridge, UK aut NATIONALLICENCE 700 1- Wutz Anton Wellcome Trust Centre for Stem Cell Research, Tennis Court Road, CB2 1QR, Cambridge, UK aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/2(2011-08-01), 295-305 0340-6717 130:2<295 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer