caa a22 4500 445861142 CHVBK 20180317145443.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00439-011-1038-1 doi (NATIONALLICENCE)springer-10.1007/s00439-011-1038-1 X chromosome inactivation in human and mouse pluripotent stem cells [Elektronische Daten] [Guoping Fan, Jamie Tran] Since the groundbreaking hypothesis of X chromosome inactivation (XCI) proposed by Mary Lyon over 50years ago, a great amount of knowledge has been gained regarding this essential dosage compensation mechanism in female cells. For the mammalian system, most of the mechanistic studies of XCI have so far been investigated in the mouse model system, but recently, a number of interesting XCI studies have been extended to human pluripotent stem cells, including both embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Emerging data indicate that XCI in hESCs and hiPSCs is much more complicated than that of their mouse counterparts. XCI in human pluripotent stem cells is not as stable and is subject to environmental influences and epigenetic regulation in vitro. This mini-review highlights the key differences in XCI between mouse and human stem cells with a greater emphasis placed on the understanding of the epigenetic regulation of XCI in human stem cells. Springer-Verlag, 2011 Fan Guoping Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles Young Drive South, 90095, Los Angeles, CA, USA aut Tran Jamie Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles Young Drive South, 90095, Los Angeles, CA, USA aut Human Genetics Springer-Verlag 130/2(2011-08-01), 217-222 0340-6717 130:2<217 2011 130 439 https://doi.org/10.1007/s00439-011-1038-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-1038-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fan Guoping Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles Young Drive South, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 700 1- Tran Jamie Department of Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, 695 Charles Young Drive South, 90095, Los Angeles, CA, USA aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/2(2011-08-01), 217-222 0340-6717 130:2<217 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer