caa a22 4500 445861177 CHVBK 20180317145443.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00439-011-1014-9 doi (NATIONALLICENCE)springer-10.1007/s00439-011-1014-9 XCI in preimplantation mouse and human embryos: first there is remodelling [Elektronische Daten] [I. van den Berg, R. Galjaard, J. Laven, J. van Doorninck] Female eutherians silence one of their X chromosomes to accomplish an equal dose of X-linked gene expression compared with males. The mouse is the most widely used animal model in XCI research and has proven to be of great significance for understanding the complex mechanism of X-linked dosage compensation. Although the basic principles of XCI are similar in mouse and humans, differences exist in the timing of XCI initiation, the genetic elements involved in XCI regulation and the form of XCI in specific tissues. Therefore, the mouse has its limitations as a model to understand early human XCI and analysis of human tissues is required. In this review, we describe these differences with respect to initiation of XCI in human and mouse preimplantation embryos, the extra-embryonic tissues and the in vitro model of the epiblast: the embryonic stem cells. The Author(s), 2011 van den Berg I. Department of Obstetrics and Gynecology, Subdivision of Reproductive Medicine, Erasmus Medical Center, Rotterdam, The Netherlands aut Galjaard R. Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands aut Laven J. Department of Obstetrics and Gynecology, Subdivision of Reproductive Medicine, Erasmus Medical Center, Rotterdam, The Netherlands aut van Doorninck J. Department of Obstetrics and Gynecology, Subdivision of Reproductive Medicine, Erasmus Medical Center, Rotterdam, The Netherlands aut Human Genetics Springer-Verlag 130/2(2011-08-01), 203-215 0340-6717 130:2<203 2011 130 439 https://doi.org/10.1007/s00439-011-1014-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-1014-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- van den Berg I. Department of Obstetrics and Gynecology, Subdivision of Reproductive Medicine, Erasmus Medical Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Galjaard R. Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Laven J. Department of Obstetrics and Gynecology, Subdivision of Reproductive Medicine, Erasmus Medical Center, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van Doorninck J. Department of Obstetrics and Gynecology, Subdivision of Reproductive Medicine, Erasmus Medical Center, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/2(2011-08-01), 203-215 0340-6717 130:2<203 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer