caa a22 4500 445861185 CHVBK 20180317145443.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s00439-011-1027-4 doi (NATIONALLICENCE)springer-10.1007/s00439-011-1027-4 A scaffold for X chromosome inactivation [Elektronische Daten] [Anna Tattermusch, Neil Brockdorff] X chromosome inactivation (XCI), the silencing of one of the two X chromosomes in XX female cells, equalises the dosage of X-linked genes relative to XY males. The process is mediated by the non-coding RNA X inactive specific transcript (Xist) that binds in cis and propagates along the inactive X chromosome elect, triggering chromosome-wide silencing. The mechanisms by which Xist RNA binds and spreads along the chromosome, and initiates Xist-mediated chromosome silencing remain poorly understood. Accumulating evidence suggests that chromosome and nuclear organisation are important in both processes. Notably, recent studies have identified specific factors, previously shown to be components of the nuclear matrix or scaffold, to play a role both in Xist RNA-binding and in Xist-mediated silencing. In this review we provide a perspective on these studies in the context of previous work on chromosome/nuclear architecture in XCI. Springer-Verlag, 2011 Tattermusch Anna Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK aut Brockdorff Neil Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK aut Human Genetics Springer-Verlag 130/2(2011-08-01), 247-253 0340-6717 130:2<247 2011 130 439 https://doi.org/10.1007/s00439-011-1027-4 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-1027-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tattermusch Anna Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK aut NATIONALLICENCE 700 1- Brockdorff Neil Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 130/2(2011-08-01), 247-253 0340-6717 130:2<247 2011 130 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer