caa a22 4500 445861398 CHVBK 20180317145444.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00439-011-0952-6 doi (NATIONALLICENCE)springer-10.1007/s00439-011-0952-6 Contribution of the IBD5 locus to inflammatory bowel disease: a meta-analysis [Elektronische Daten] [Jian Wang, Xi Wang, Hong Yang, Dong Wu, Li Wang, Jiaming Qian] To evaluate the association of the IBD5 locus to the predisposition of inflammatory bowel diseases (IBDs), a series of meta-analyses between five IBD5 variants (OCTN1 C1672T, OCTN2 G-207C, OCTN1/2 TC haplotype, IGR2096a_1, IGR2198a_1 and IGR2230a_1) and Crohn's disease (CD) and ulcerative colitis (UC) were performed, which included a total of 26 studies. Overall, five IBD5 variants in a per-allele model of inheritance were significantly associated with elevated CD risk (for OCTN1: OR=1.23, 95% CI=1.16-1.30, P<0.001; for OCTN2: OR=1.20, 95% CI=1.11-1.30, P<0.001; for IGR2096a_1: OR=1.36, 95% CI=1.24-1.46, P<0.001; for IGR2198a_1: OR=1.34, 95% CI=1.24-1.46, P<0.001; for IGR2230a_1: OR=1.35, 95% CI=1.23-1.48, P<0.001) and OCTN1/2 TC haplotype (OR=1.32, 95% CI=1.22-1.43, P<0.001). In the subgroup analysis, the statistically significant associations were also observed in adult- and pediatric-onset CD and in Caucasians for five IBD5 variants and the OCTN1/2 TC haplotype. A statistically significant increase in the risk of UC was detected in a recessive model of inheritances for OCTN1 (OR=1.23, 95% CI=1.08-1.40, P<0.001), OCTN2 (OR=1.18, 95% CI=1.05-1.33, P=0.006), IGR2096a_1 (OR=1.37, 95% CI=1.15-1.62, P<0.001) and IGR2198a_1 (OR=1.35, 95% CI=1.10-1.66, P=0.004); the increased risks of UC were maintained in the adult and Caucasian subgroups, but not the pediatric subgroup. In summary, our results suggested that the IBD5 locus contributes to the susceptibility of CD in a per-allele manner in adults, children and Caucasians, and the locus contributes to the susceptibility of UC in a recessive manner in adult and Caucasian populations. Springer-Verlag, 2011 Wang Jian Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut Wang Xi Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut Yang Hong Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut Wu Dong Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut Wang Li Department of Epidemiology, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut Qian Jiaming Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut Human Genetics Springer-Verlag 129/6(2011-06-01), 597-609 0340-6717 129:6<597 2011 129 439 https://doi.org/10.1007/s00439-011-0952-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-0952-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Jian Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Wang Xi Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Yang Hong Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Wu Dong Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Wang Li Department of Epidemiology, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut NATIONALLICENCE 700 1- Qian Jiaming Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, 100730, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 129/6(2011-06-01), 597-609 0340-6717 129:6<597 2011 129 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer