caa a22 4500 445861428 CHVBK 20180317145444.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00439-011-0955-3 doi (NATIONALLICENCE)springer-10.1007/s00439-011-0955-3 Lingo2 variants associated with essential tremor and Parkinson's disease [Elektronische Daten] [Yi-Wen Wu, K. Prakash, Tian-Yi Rong, Hui-Hua Li, Qin Xiao, Louis Tan, Wing-Lok Au, Jian-qing Ding, Sheng-di Chen, Eng-King Tan] LINGO2, a member of LRR gene family, has been linked with both Essential tremor (ET) and Parkinson's disease (PD). However, there is a lack of conclusive evidence regarding the etiologic role of LINGO2 genetic variants. We investigated the association of LINGO2 variants with ET and PD in two independent Asian countries. A total of 1,262 subjects comprising 499 controls, 436 PD patients, and 327 ET patients were included. Eight LINGO2 variants, including four single-nucleotide polymorphisms (SNPs) and four coding variants, were initially analyzed in one Asian population. SNPs that showed positive association were then replicated in the second independent Asian population, and a pooled analysis was carried out. Out of the eight variants, two SNPs (rs7033345 and rs10812774) revealed significant or strong positive trend in the first Asian population, and these were analyzed in the second Asian population. In the pooled analysis, the CC genotype at rs7033345 had a higher risk of developing PD (OR=1.67, 95% CI=1.18, 2.35, p=0.003) and ET (OR=1.50, 95% CI=1.02, 2.20, p=0.04) under a recessive model. The C allele at rs10812774 increased the risk of ET (OR=1.56 95% CI=1.10, 2.22, p=0.01) via a recessive model. The effect size and direction of trend were in the same direction in each of the two populations. Our study demonstrated for the first time that rs7033345 is associated with PD and ET and rs10812774 with ET among Asians, suggesting that LINGO2 might act as a susceptibility gene for both conditions. Springer-Verlag, 2011 Wu Yi-Wen Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut Prakash K. Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut Rong Tian-Yi Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut Li Hui-Hua Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut Xiao Qin Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut Tan Louis Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut Au Wing-Lok Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut Ding Jian-qing Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut Chen Sheng-di Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut Tan Eng-King Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut Human Genetics Springer-Verlag 129/6(2011-06-01), 611-615 0340-6717 129:6<611 2011 129 439 https://doi.org/10.1007/s00439-011-0955-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-011-0955-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wu Yi-Wen Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Prakash K. Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut NATIONALLICENCE 700 1- Rong Tian-Yi Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Li Hui-Hua Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut NATIONALLICENCE 700 1- Xiao Qin Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Tan Louis Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut NATIONALLICENCE 700 1- Au Wing-Lok Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut NATIONALLICENCE 700 1- Ding Jian-qing Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Chen Sheng-di Department of Neurology, Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, 200025, Shanghai, China aut NATIONALLICENCE 700 1- Tan Eng-King Departments of Neurology and Clinical Research, Singapore General Hospital, National Neuroscience Institute, Duke-NUS Graduate Medical School, Outram Road, 169608, Singapore, Singapore aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 129/6(2011-06-01), 611-615 0340-6717 129:6<611 2011 129 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer