caa a22 4500 445861673 CHVBK 20180317145445.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00439-010-0939-8 doi (NATIONALLICENCE)springer-10.1007/s00439-010-0939-8 Model-based prediction of human hair color using DNA variants [Elektronische Daten] [Wojciech Branicki, Fan Liu, Kate van Duijn, Jolanta Draus-Barini, Ewelina Pośpiech, Susan Walsh, Tomasz Kupiec, Anna Wojas-Pelc, Manfred Kayser] Predicting complex human phenotypes from genotypes is the central concept of widely advocated personalized medicine, but so far has rarely led to high accuracies limiting practical applications. One notable exception, although less relevant for medical but important for forensic purposes, is human eye color, for which it has been recently demonstrated that highly accurate prediction is feasible from a small number of DNA variants. Here, we demonstrate that human hair color is predictable from DNA variants with similarly high accuracies. We analyzed in Polish Europeans with single-observer hair color grading 45 single nucleotide polymorphisms (SNPs) from 12 genes previously associated with human hair color variation. We found that a model based on a subset of 13 single or compound genetic markers from 11 genes predicted red hair color with over 0.9, black hair color with almost 0.9, as well as blond, and brown hair color with over 0.8 prevalence-adjusted accuracy expressed by the area under the receiver characteristic operating curves (AUC). The identified genetic predictors also differentiate reasonably well between similar hair colors, such as between red and blond-red, as well as between blond and dark-blond, highlighting the value of the identified DNA variants for accurate hair color prediction. The Author(s), 2010 Branicki Wojciech Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31-033, Kraków, Poland aut Liu Fan Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut van Duijn Kate Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut Draus-Barini Jolanta Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31-033, Kraków, Poland aut Pośpiech Ewelina Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31-033, Kraków, Poland aut Walsh Susan Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut Kupiec Tomasz Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31-033, Kraków, Poland aut Wojas-Pelc Anna Department of Dermatology, Collegium Medicum of the Jagiellonian University, Kopernika 19, 31-501, Kraków, Poland aut Kayser Manfred Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut Human Genetics Springer-Verlag 129/4(2011-04-01), 443-454 0340-6717 129:4<443 2011 129 439 https://doi.org/10.1007/s00439-010-0939-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00439-010-0939-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Branicki Wojciech Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31-033, Kraków, Poland aut NATIONALLICENCE 700 1- Liu Fan Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- van Duijn Kate Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Draus-Barini Jolanta Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31-033, Kraków, Poland aut NATIONALLICENCE 700 1- Pośpiech Ewelina Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31-033, Kraków, Poland aut NATIONALLICENCE 700 1- Walsh Susan Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 700 1- Kupiec Tomasz Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31-033, Kraków, Poland aut NATIONALLICENCE 700 1- Wojas-Pelc Anna Department of Dermatology, Collegium Medicum of the Jagiellonian University, Kopernika 19, 31-501, Kraków, Poland aut NATIONALLICENCE 700 1- Kayser Manfred Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands aut NATIONALLICENCE 773 0- Human Genetics Springer-Verlag 129/4(2011-04-01), 443-454 0340-6717 129:4<443 2011 129 439 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer