caa a22 4500 445869763 CHVBK 20180317145508.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s11101-010-9184-y doi (NATIONALLICENCE)springer-10.1007/s11101-010-9184-y The evolution of pyrrolizidine alkaloid biosynthesis and diversity in the Senecioneae [Elektronische Daten] [Dorothee Langel, Dietrich Ober, Pieter Pelser] Pyrrolizidine alkaloids are characteristic secondary metabolites of the Asteraceae and some other plant families. They are especially numerous and diverse in the tribe Senecioneae and form a powerful defense mechanism against herbivores. Studies into the evolution of pyrrolizidine alkaloid biosynthesis using Senecio species have identified homospermidine synthase as the enzyme responsible for the synthesis of the first specific intermediate. These studies further indicated that the homospermidine synthase-encoding gene was recruited following gene duplication of deoxyhypusine synthase and that this occurred independently in several different angiosperm lineages. A review of published pyrrolizidine alkaloid data shows that the Senecioneae are characterized by a large qualitative and quantitative variation in pyrrolizidine alkaloid profiles and that these data demonstrate little phylogenetic signal. This suggests that although the first steps of this pathway are highly conserved, the diversification of secondarily derived pyrrolizidine alkaloids is extremely plastic. Springer Science+Business Media B.V., 2010 Chemotaxonomy nationallicence Deoxyhypusine synthase nationallicence Homospermidine synthase nationallicence Secondary metabolism nationallicence Structure diversification nationallicence cDNA : Complementary DNA nationallicence DHS : Deoxyhypusine synthase nationallicence E. coli : Escherichia coli nationallicence eIF5A : Eukaryotic initiation factor 5A nationallicence HSS : Homospermidine synthase nationallicence J . : Jacobaea nationallicence PA(s) : Pyrrolizidine alkaloid(s) nationallicence S . : Senecio nationallicence Langel Dorothee Biochemische Ökologie und Molekulare Evolution, Botanisches Institut und Botanischer Garten, Christian-Albrechts-Universität zu Kiel, Olshausenstraße 40, 24098, Kiel, Germany aut Ober Dietrich Biochemische Ökologie und Molekulare Evolution, Botanisches Institut und Botanischer Garten, Christian-Albrechts-Universität zu Kiel, Olshausenstraße 40, 24098, Kiel, Germany aut Pelser Pieter School of Biological Sciences, University of Canterbury, Private Bag 4800, 8140, Christchurch, New Zealand aut Phytochemistry Reviews Springer Netherlands 10/1(2011-03-01), 3-74 1568-7767 10:1<3 2011 10 11101 https://doi.org/10.1007/s11101-010-9184-y text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11101-010-9184-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Langel Dorothee Biochemische Ökologie und Molekulare Evolution, Botanisches Institut und Botanischer Garten, Christian-Albrechts-Universität zu Kiel, Olshausenstraße 40, 24098, Kiel, Germany aut NATIONALLICENCE 700 1- Ober Dietrich Biochemische Ökologie und Molekulare Evolution, Botanisches Institut und Botanischer Garten, Christian-Albrechts-Universität zu Kiel, Olshausenstraße 40, 24098, Kiel, Germany aut NATIONALLICENCE 700 1- Pelser Pieter School of Biological Sciences, University of Canterbury, Private Bag 4800, 8140, Christchurch, New Zealand aut NATIONALLICENCE 773 0- Phytochemistry Reviews Springer Netherlands 10/1(2011-03-01), 3-74 1568-7767 10:1<3 2011 10 11101 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer