caa a22 4500 445869836 CHVBK 20180317145508.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s11101-011-9209-1 doi (NATIONALLICENCE)springer-10.1007/s11101-011-9209-1 The chemical and biological activities of quinones: overview and implications in analytical detection [Elektronische Daten] [Nahed El-Najjar, Hala Gali-Muhtasib, Raimo Ketola, Pia Vuorela, Arto Urtti, Heikki Vuorela] Quinones are a class of natural and synthetic compounds that have several beneficial effects. Quinones are electron carriers playing a role in photosynthesis. As vitamins, they represent a class of molecules preventing and treating several illnesses such as osteoporosis and cardiovascular diseases. Quinones, by their antioxidant activity, improve general health conditions. Many of the drugs clinically approved or still in clinical trials against cancer are quinone related compounds. Quinones have also toxicological effects through their presence as photoproducts from air pollutants. Quinones are fast redox cycling molecules and have the potential to bind to thiol, amine and hydroxyl groups. The aforementioned properties make the analytical detection of quinones problematic. However, recent advances of the available analytical techniques along with the possibility of using labeled compound facilitate their detection hence allowing a better understanding of their action. This review summarizes the current knowledge with respect to the oxido-reductive and electrophilic properties of quinones as well as to the analytical tools used for their analysis. It includes a general introduction about the physiological, and therapeutical functions of quinones. A number of studies are reported to cover the chemical reactivity in an attempt to understand quinones as biologically active compounds. Data ranging from normal analytical methods to study quinones derived from plant or biological matrices to the use of labeled compounds are presented. The examples illustrate how chemical, biological and analytical knowledge can be integrated to have a better understanding of the mode of action of the quinones. Springer Science+Business Media B.V., 2011 Quinone nationallicence Chemotherapeutic agents nationallicence One electron reduction nationallicence Two electron reduction nationallicence Labeled compounds analysis nationallicence El-Najjar Nahed Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, P.O. Box 56, 00014, Helsinki, Finland aut Gali-Muhtasib Hala Department of Biology, American University of Beirut, Beirut, Lebanon aut Ketola Raimo Center for Drug Research, University of Helsinki, Helsinki, Finland aut Vuorela Pia Pharmaceutical Sciences, Department of Biosciences, Abo Akademi University, Turku, Finland aut Urtti Arto Center for Drug Research, University of Helsinki, Helsinki, Finland aut Vuorela Heikki Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, P.O. Box 56, 00014, Helsinki, Finland aut Phytochemistry Reviews Springer Netherlands 10/3(2011-09-01), 353-370 1568-7767 10:3<353 2011 10 11101 https://doi.org/10.1007/s11101-011-9209-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11101-011-9209-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- El-Najjar Nahed Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, P.O. Box 56, 00014, Helsinki, Finland aut NATIONALLICENCE 700 1- Gali-Muhtasib Hala Department of Biology, American University of Beirut, Beirut, Lebanon aut NATIONALLICENCE 700 1- Ketola Raimo Center for Drug Research, University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 700 1- Vuorela Pia Pharmaceutical Sciences, Department of Biosciences, Abo Akademi University, Turku, Finland aut NATIONALLICENCE 700 1- Urtti Arto Center for Drug Research, University of Helsinki, Helsinki, Finland aut NATIONALLICENCE 700 1- Vuorela Heikki Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Viikinkaari 5E, P.O. Box 56, 00014, Helsinki, Finland aut NATIONALLICENCE 773 0- Phytochemistry Reviews Springer Netherlands 10/3(2011-09-01), 353-370 1568-7767 10:3<353 2011 10 11101 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer