caa a22 4500 445869895 CHVBK 20180317145508.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s11101-010-9201-1 doi (NATIONALLICENCE)springer-10.1007/s11101-010-9201-1 Bioactive lichen metabolites: alpine habitats as an untapped source [Elektronische Daten] [Joel Boustie, Sophie Tomasi, Martin Grube] Lichens are fungal and algal/cyanobacterial symbioses resulting in the production of specific metabolites. Some of these are forming an available biomass for phytochemical investigations, including the assessment of biological activities of the isolated compounds. The alpine or polar region are characterised by highly stressful environmental conditions for many organisms, but lichens are among the dominating organisms in these habitats. In the performant mutual protective system, lichen fungi often accumulate high amounts of metabolites with specific physicochemical properties (UV absorbents, hydrophobicity) which help the lichens to survive. Unique secondary metabolites and polysaccharides have been isolated and tested from these organisms. Even though this has been tested until now only with a low number of compounds so far, interesting activities have been recorded. We review here some of the antimicrobial, anti-inflammatory, antiproliferative and antioxidant activities properties described. Solutions with axenic biotechnological cultivation of each symbiotic partner and particularly the mycobiont to obtain the lichen secondary metabolites are challenging to overcome the limitations for the supply of these rare compounds. Additionally, these lichens appear to harbour a diversity of culturable microorganisms from which active compounds have also been isolated recently. Springer Science+Business Media B.V., 2010 Bioactivity nationallicence Cold habitat nationallicence Natural compounds nationallicence Pharmacy nationallicence Symbiosis nationallicence Boustie Joel Faculté de Pharmacie, Sciences chimiques de Rennes, équipe PNSCM Produits naturels - Synthèses - Chimie médicinale, UMR CNRS 6226, Université de Rennes 1, Université Européenne de Bretagne, 2 av du Pr. Léon Bernard, 35043, Rennes Cédex, France aut Tomasi Sophie Faculté de Pharmacie, Sciences chimiques de Rennes, équipe PNSCM Produits naturels - Synthèses - Chimie médicinale, UMR CNRS 6226, Université de Rennes 1, Université Européenne de Bretagne, 2 av du Pr. Léon Bernard, 35043, Rennes Cédex, France aut Grube Martin Institut für Pflanzenwissenschaften, Karl-Franzens-Universität Graz, Holteigasse 6, 8010, Graz, Austria aut Phytochemistry Reviews Springer Netherlands 10/3(2011-09-01), 287-307 1568-7767 10:3<287 2011 10 11101 https://doi.org/10.1007/s11101-010-9201-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11101-010-9201-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Boustie Joel Faculté de Pharmacie, Sciences chimiques de Rennes, équipe PNSCM Produits naturels - Synthèses - Chimie médicinale, UMR CNRS 6226, Université de Rennes 1, Université Européenne de Bretagne, 2 av du Pr. Léon Bernard, 35043, Rennes Cédex, France aut NATIONALLICENCE 700 1- Tomasi Sophie Faculté de Pharmacie, Sciences chimiques de Rennes, équipe PNSCM Produits naturels - Synthèses - Chimie médicinale, UMR CNRS 6226, Université de Rennes 1, Université Européenne de Bretagne, 2 av du Pr. Léon Bernard, 35043, Rennes Cédex, France aut NATIONALLICENCE 700 1- Grube Martin Institut für Pflanzenwissenschaften, Karl-Franzens-Universität Graz, Holteigasse 6, 8010, Graz, Austria aut NATIONALLICENCE 773 0- Phytochemistry Reviews Springer Netherlands 10/3(2011-09-01), 287-307 1568-7767 10:3<287 2011 10 11101 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer