caa a22 4500 445869992 CHVBK 20180317145508.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s11101-010-9172-2 doi (NATIONALLICENCE)springer-10.1007/s11101-010-9172-2 Anti-HIV activity of natural triterpenoids and hemisynthetic derivatives 2004-2009 [Elektronische Daten] [Bruce Cassels, Marcelo Asencio] The continued advance of HIV-AIDS makes the development of relatively inexpensive, freely accessible, and mechanistically more diverse antiviral therapies an urgent need. Natural products are, directly or indirectly, an important potential source of compounds meeting these conditions. A review of the recent literature indicates that some hemisynthetic triterpenoid derivatives, particularly belonging to the lupane, oleanane and ursane series, may be nearing a stage where they can be used to complement existing therapeutic approaches. On the other hand, although some natural derivatives of tetracyclic terpenoid families have revealed many novel structures and some promise as anti-HIV substances, their chemical modification to improve their potency and selectivity remains practically untouched. While ongoing work with the more ‘classical' pentacyclic triterpenoids will continue to be a fertile field for HIV-AIDS drug discovery, the other structural groups offer unprecedented opportunities for the development of additional substances with useful properties and for the discovery of novel targets for antiviral therapy. Springer Science+Business Media B.V., 2010 AIDS nationallicence Antiviral activity nationallicence Natural products nationallicence Triterpenes nationallicence Structural modification nationallicence Cassels Bruce Department of Chemistry, Faculty of Sciences, University of Chile, Las Palmeras 3425, Ñuñoa, Santiago, Chile aut Asencio Marcelo Bioinorganic and Natural Products Chemistry Laboratory, Faculty of Ecology, Mathematics and the Environment, Metropolitan Technological University, J.P. Alessandri 1242, Ñuñoa, Santiago, Chile aut Phytochemistry Reviews Springer Netherlands 10/4(2011-12-01), 545-564 1568-7767 10:4<545 2011 10 11101 https://doi.org/10.1007/s11101-010-9172-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11101-010-9172-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cassels Bruce Department of Chemistry, Faculty of Sciences, University of Chile, Las Palmeras 3425, Ñuñoa, Santiago, Chile aut NATIONALLICENCE 700 1- Asencio Marcelo Bioinorganic and Natural Products Chemistry Laboratory, Faculty of Ecology, Mathematics and the Environment, Metropolitan Technological University, J.P. Alessandri 1242, Ñuñoa, Santiago, Chile aut NATIONALLICENCE 773 0- Phytochemistry Reviews Springer Netherlands 10/4(2011-12-01), 545-564 1568-7767 10:4<545 2011 10 11101 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer