caa a22 4500 44587547X CHVBK 20180317145526.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10593-011-0720-5 doi (NATIONALLICENCE)springer-10.1007/s10593-011-0720-5 Solvent-free one-pot synthesis, characterization, antibacterial and antifungal activities of novel spiropiperidinyl-1,2,4-triazolidine-3-thiones [Elektronische Daten] [V. Kanagarajan, J. Thanusu, M. Ezhilarasi, M. Gopalakrishnan] A novel approach towards the synthesis of spiropiperidinyl 1,2,4-triazolidine-3-thiones was proposed, exploiting microwave activation coupled with solvent-free reaction conditions. In search for new leads towards potent antimicrobial agents, we tested all the synthesized compounds for their in vitro antibacterial activity against Bacillus subtilis and Micrococcus luteus and antifungal activity against Aspergillus niger, Candida albicans, Candida-6, and Candida-51. Two of the compounds exerted strong in vitro antibacterial activity against B. subtilis and M. luteus, and all the synthesized compounds were potent against the tested fungal strains. Springer Science+Business Media, Inc., 2011 m -chloro-perbenzoic acid nationallicence spiropiperidinyl-1,2,4-triazolidine-3-thiones nationallicence antibacterial activity nationallicence antifungal activity nationallicence one-pot synthesis nationallicence Kanagarajan V. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India aut Thanusu J. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India aut Ezhilarasi M. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India aut Gopalakrishnan M. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/1(2011-04-01), 60-66 0009-3122 47:1<60 2011 47 10593 https://doi.org/10.1007/s10593-011-0720-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0720-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kanagarajan V. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India aut NATIONALLICENCE 700 1- Thanusu J. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India aut NATIONALLICENCE 700 1- Ezhilarasi M. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India aut NATIONALLICENCE 700 1- Gopalakrishnan M. Synthetic Organic Chemistry Laboratory, Department of Chemistry, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/1(2011-04-01), 60-66 0009-3122 47:1<60 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer