caa a22 4500 44587550X CHVBK 20180317145526.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10593-011-0721-4 doi (NATIONALLICENCE)springer-10.1007/s10593-011-0721-4 4-Hydroxy-2-quinolones. 195*. Synthesis of novel, potential analgesics based on 4-(hetarylmethyl)amino-2-oxo-1,2-dihydro-quinoline-3-carboxylic acids [Elektronische Daten] [I. Ukrainets, E. Mospanova, L. Savchenkova, S. Yankovich] From the viewpoint of the method of bioisosteric replacement we have carried out the synthesis of a series of 4-(hetarylmethyl)amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acids. For several examples it has been shown experimentally that the aromatic ring in the benzyl fragment of 4-benzylamino-2-oxo-1,2-dihydroquinoline-3-carboxylic acid can be replaced by an isosteric heterocycle without lowering the analgesic properties. Springer Science+Business Media, Inc., 2011 4-N-R-2-oxo-1,2-dihydroquinoline-3-carboxylic acids nationallicence analgesic activity nationallicence bioisosteric replacement nationallicence Ukrainets I. National Pharmaceutical University, Pushkin Str., 53, 61002, Kharkiv, Ukraine aut Mospanova E. Institute of Chemical Technology, V. Dal East-Ukrainian National University, Lenin Str., 31, 93003, Rubizhne, Ukraine aut Savchenkova L. Luhansk State Medical University, 1 Kvartal 50-richia Oborony Luhanska, 91045, Luhansk, Ukraine aut Yankovich S. Luhansk State Medical University, 1 Kvartal 50-richia Oborony Luhanska, 91045, Luhansk, Ukraine aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/1(2011-04-01), 67-73 0009-3122 47:1<67 2011 47 10593 https://doi.org/10.1007/s10593-011-0721-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0721-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ukrainets I. National Pharmaceutical University, Pushkin Str., 53, 61002, Kharkiv, Ukraine aut NATIONALLICENCE 700 1- Mospanova E. Institute of Chemical Technology, V. Dal East-Ukrainian National University, Lenin Str., 31, 93003, Rubizhne, Ukraine aut NATIONALLICENCE 700 1- Savchenkova L. Luhansk State Medical University, 1 Kvartal 50-richia Oborony Luhanska, 91045, Luhansk, Ukraine aut NATIONALLICENCE 700 1- Yankovich S. Luhansk State Medical University, 1 Kvartal 50-richia Oborony Luhanska, 91045, Luhansk, Ukraine aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/1(2011-04-01), 67-73 0009-3122 47:1<67 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer