caa a22 4500 445875801 CHVBK 20180317145527.0 cr unu---uuuuu 170323e20110901xx s 000 0 eng 10.1007/s10593-011-0823-z doi (NATIONALLICENCE)springer-10.1007/s10593-011-0823-z An efficient synthesis of 2,4′-bi-1,3-oxa(thia)zoles as scaffolds for bioactive products [Elektronische Daten] [S. Peña, L. Scarone, E. Manta, G. Serra] A rapid and efficient methodology to prepare 2,4′-bi-1,3-azoles as scaffolds for biologically active marine natural products is described. Hantzsch reaction and oxidative cyclodehydration of β-hydroxy amides or thioamides were used to construct the azole rings. The obtained biheterocycles displayed no cytotoxicity on HCT-15 cell line. Springer Science+Business Media, Inc., 2011 bi-1,3-azoles nationallicence α-halo ketone nationallicence β-hydroxy amides nationallicence Hantzsch reaction nationallicence oxidative cyclodehydration nationallicence Peña S. Quimica Farmaceutica Facultad de Quimica, 2124, Montevideo, Uruguay aut Scarone L. Quimica Farmaceutica Facultad de Quimica, 2124, Montevideo, Uruguay aut Manta E. Quimica Farmaceutica Facultad de Quimica, 2124, Montevideo, Uruguay aut Serra G. Quimica Farmaceutica Facultad de Quimica, 2124, Montevideo, Uruguay aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/6(2011-09-01), 703-709 0009-3122 47:6<703 2011 47 10593 https://doi.org/10.1007/s10593-011-0823-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0823-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Peña S. Quimica Farmaceutica Facultad de Quimica, 2124, Montevideo, Uruguay aut NATIONALLICENCE 700 1- Scarone L. Quimica Farmaceutica Facultad de Quimica, 2124, Montevideo, Uruguay aut NATIONALLICENCE 700 1- Manta E. Quimica Farmaceutica Facultad de Quimica, 2124, Montevideo, Uruguay aut NATIONALLICENCE 700 1- Serra G. Quimica Farmaceutica Facultad de Quimica, 2124, Montevideo, Uruguay aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/6(2011-09-01), 703-709 0009-3122 47:6<703 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer