caa a22 4500 445876085 CHVBK 20180317145528.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10593-011-0844-7 doi (NATIONALLICENCE)springer-10.1007/s10593-011-0844-7 Application of the heck reaction for the synthesis of 1-alkoxyisoquinoline- 3-carboxylic acids esters [Elektronische Daten] [A. Ture, K. Rubina, E. Rozhkov, V. Kauss] It has been shown that the cyclization of the methyl 2-(2,2,2-trifluoroacetylamino)acrylate arylation product using methyl 4,6-dichloro-2-iodobenzoate gives the corresponding 1-methoxyisoquinoline-3-carboxylic acid ester through loss of water rather than methanol. This feature of the condensation has been used for the synthesis of methyl 1-(tert-butoxycarbonylmethoxy)isoquinoline-3-carboxylate. Springer Science+Business Media, Inc., 2011 2-iodobenzoic acids nationallicence methyl 2-(2,2,2-trifluoroacetylamino)acrylate nationallicence 1-oxo-1,2-dihydro-quinoline-3-carboxylic acid nationallicence condensation nationallicence Heck reaction nationallicence Ture A. Latvian Institute for Organic Synthesis, 21 Aizkraukles St., LV-1006, Riga, Latvia aut Rubina K. Latvian Institute for Organic Synthesis, 21 Aizkraukles St., LV-1006, Riga, Latvia aut Rozhkov E. Latvian Institute for Organic Synthesis, 21 Aizkraukles St., LV-1006, Riga, Latvia aut Kauss V. Latvian Institute for Organic Synthesis, 21 Aizkraukles St., LV-1006, Riga, Latvia aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/7(2011-10-01), 838-844 0009-3122 47:7<838 2011 47 10593 https://doi.org/10.1007/s10593-011-0844-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0844-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ture A. Latvian Institute for Organic Synthesis, 21 Aizkraukles St., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Rubina K. Latvian Institute for Organic Synthesis, 21 Aizkraukles St., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Rozhkov E. Latvian Institute for Organic Synthesis, 21 Aizkraukles St., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Kauss V. Latvian Institute for Organic Synthesis, 21 Aizkraukles St., LV-1006, Riga, Latvia aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/7(2011-10-01), 838-844 0009-3122 47:7<838 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer