caa a22 4500 445876123 CHVBK 20180317145528.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10593-011-0849-2 doi (NATIONALLICENCE)springer-10.1007/s10593-011-0849-2 Facile TICl4-catalyzed synthesis of novel 1,2,4-triazoles appended to thiazoles [Elektronische Daten] [T. Gireesh, R. Kamble, R. Hunnur, T. Taj, M. Kariduraganavar] The reaction of sydnone-derived 3-aryl-5-methyl-1,3,4-oxadiazol-2(3H)-ones with thiourea and α-bromoacetophenone derivatives in the presence of a catalytic amount of TiCl4 produces 2-aryl-4-(4-aryl-1,3-thiazol-2-yl)-5-methyl-2,4-dihydro-3H-1,2,4-triazol-3-ones. The title compounds were screened for their antibacterial and antifungal activity. The toxicity of the compounds was evaluated in terms of mutagenicity, tumorigenicity, and reproductive effects. The drug-relevant properties (ClogP, drug-likeness, and drug score) were calculated, and the structure-activity relationship was discussed. Springer Science+Business Media, Inc., 2011 mesoionic compounds nationallicence sydnones nationallicence TiCl4 nationallicence 1,3-dipolar cycloaddition nationallicence Gireesh T. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut Kamble R. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut Hunnur R. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut Taj T. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut Kariduraganavar M. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/7(2011-10-01), 877-885 0009-3122 47:7<877 2011 47 10593 https://doi.org/10.1007/s10593-011-0849-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0849-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gireesh T. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut NATIONALLICENCE 700 1- Kamble R. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut NATIONALLICENCE 700 1- Hunnur R. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut NATIONALLICENCE 700 1- Taj T. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut NATIONALLICENCE 700 1- Kariduraganavar M. PG Department of Studies in Chemistry, Karnatak University, 580003, Dharwad, India aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/7(2011-10-01), 877-885 0009-3122 47:7<877 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer